{"id":107673,"date":"2018-03-11T10:32:06","date_gmt":"2018-03-11T10:32:06","guid":{"rendered":""},"modified":"2018-03-11T10:32:06","modified_gmt":"2018-03-11T10:32:06","slug":"acid-ceramidase-and-sphingosine-1-phosphate-lyase-as-biomarkers-and-therapeutic-targets-in-cancer-ceramidasa-acida-y-esfingosina-1-fosfato-liasa-como-biomarcadores-y-dianas-terapeuticas-en-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/acid-ceramidase-and-sphingosine-1-phosphate-lyase-as-biomarkers-and-therapeutic-targets-in-cancer-ceramidasa-acida-y-esfingosina-1-fosfato-liasa-como-biomarcadores-y-dianas-terapeuticas-en-cancer\/","title":{"rendered":"Acid ceramidase and sphingosine-1-phosphate lyase as biomarkers and therapeutic targets in cancer (ceramidasa \u00e1cida y esfingosina-1-fosfato liasa como biomarcadores y dianas terap\u00e9uticas en c\u00e1ncer)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luz Del Carmen Camacho  Castillo <\/strong><\/h2>\n<p>Los esfingol\u00edpidos poseen un papel fundamental como mediadores en los procesos de proliferaci\u00f3n, diferenciaci\u00f3n y muerte celular. Los principales esfingol\u00edpidos bioactivos son: ceramida, esfingosina, ceramida-1-fosfato y esfingosina-1-fosfato. La ceramida es el centro de la ruta de s\u00edntesis y degradaci\u00f3n de dichos compuestos, su producci\u00f3n se incrementa en repuesta a est\u00edmulos de estr\u00e9s y activa rutas metab\u00f3licas encaminadas a producir la muerte celular; por otro lado, su transformaci\u00f3n en ceramida 1-fosfato (c1p) o esfingosina y esfingosina-1-fosfato (s1p) activa v\u00edas mitog\u00e9nicas que regulan la diferenciaci\u00f3n y proliferaci\u00f3n celular. Las enzimas responsables de la degradaci\u00f3n de la ceramida son las ceramidasas. Por otro lado, la enzima esfingosina-1-fosfato liasa (s1pl), se encarga de degradaci\u00f3n de la esfingosina-1-fosfato, por lo que es una diana terap\u00e9utica novedosa. En base a lo anterior, los objetivos de este trabajo fueron optimizar y validar los ensayos enzim\u00e1ticos fluorog\u00e9nicos desarrollados por el grupo de trabajo para la determinaci\u00f3n de la actividad de las enzimas s1pl y ceramidasas, as\u00ed como su aplicaci\u00f3n a diagn\u00f3stico, su potencial como biomarcadores en c\u00e1ncer y a la identificaci\u00f3n de inhibidores espec\u00edficos, adem\u00e1s de investigar el papel de la ceramidasa \u00e1cida en un modelo de c\u00e1ncer de pr\u00f3stata avanzado. Como resultado de este trabajo se desarrollo un m\u00e9todo para el diagn\u00f3stico de la enfermedad de farber utilizando un sustrato fluorog\u00e9nico para la ceramidasa \u00e1cida y dos m\u00e9todos para determinar la actividad de la enzima s1pl.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acid ceramidase and sphingosine-1-phosphate lyase as biomarkers and therapeutic targets in cancer (ceramidasa \u00e1cida y esfingosina-1-fosfato liasa como biomarcadores y dianas terap\u00e9uticas en c\u00e1ncer).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acid ceramidase and sphingosine-1-phosphate lyase as biomarkers and therapeutic targets in cancer (ceramidasa \u00e1cida y esfingosina-1-fosfato liasa como biomarcadores y dianas terap\u00e9uticas en c\u00e1ncer). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luz Del Carmen Camacho  Castillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gemma Fabrias Domingo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lLuisa Vilageliu arqu\u00e9s <\/li>\n<li>Marta Cascante serratosa (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luz Del Carmen Camacho Castillo Los esfingol\u00edpidos poseen un papel fundamental como mediadores en los procesos de 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