{"id":107727,"date":"2011-01-04T00:00:00","date_gmt":"2011-01-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-quinasa-humana-vrk2a-un-nuevo-modulador-negativo-de-la-ruta-de-senalizacion-de-erk1-2\/"},"modified":"2011-01-04T00:00:00","modified_gmt":"2011-01-04T00:00:00","slug":"la-quinasa-humana-vrk2a-un-nuevo-modulador-negativo-de-la-ruta-de-senalizacion-de-erk1-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/la-quinasa-humana-vrk2a-un-nuevo-modulador-negativo-de-la-ruta-de-senalizacion-de-erk1-2\/","title":{"rendered":"La quinasa humana vrk2a, un nuevo modulador negativo de la ruta de se\u00f1alizaci\u00f3n de erk1\/2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Fernandez Fernandez <\/strong><\/h2>\n<p>La familia de serina-treonina quinasas vrk se compone de 3 miembros vrk1, vrk2 y vrk3. Vrk2 presenta 2 isoformas vrk2a y vrk2b generadas por un procesamiento alternativo del arnm y existen a\u00fan pocos datos acerca de la funci\u00f3n biol\u00f3gica de estas quinasas.  \tinicialmente, estudiamos los patrones de expresi\u00f3n de vrk2 en tejidos tanto normales como tumorales de mama as\u00ed como en un panel de l\u00edneas celulares de mama. En nuestro estudio pudimos observar como existe una correlaci\u00f3n inversa entre los niveles de expresi\u00f3n del receptor erbb2 y la quinasa vrk2. En cambio, la expresi\u00f3n de vrk2 correlaciona positivamente con la de los receptores de estr\u00f3geno y progesterona. Estas observaciones nos llevan a hipotetizar que vrk2 se comporta en los tumores de mama como un marcador de buen pron\u00f3stico.  \tposteriormente, determinamos que vrk2a modula negativamente la ruta de se\u00f1alizaci\u00f3n de erk1\/2, actuando por debajo de mek. Adem\u00e1s, vrk2a es capaz de modular la respuesta al factor de crecimiento epid\u00e9rmico (egf). Por otro lado, hemos observado que el mecanismo por el cual vrk2a modula la ruta de se\u00f1alizaci\u00f3n de erk es independiente de su actividad quinasa y ha de deberse por tanto a interacciones prote\u00edna-prote\u00edna. Para profundizar en el mecanismo de acci\u00f3n decidimos validar posibles interacciones de vrk2a con prote\u00ednas de la ruta de se\u00f1alizaci\u00f3n de erk1\/2. Vrk2a no interacciona con b-raf ni con erk. Sin embargo interacciona de forma directa con mek a trav\u00e9s de su extremo amino terminal. Adem\u00e1s, hemos observado que vrk2a interacciona con la prote\u00edna scaffold ksr1, siendo esta interacci\u00f3n espec\u00edfica de vrk2a. Vrk2a colocaliza con ksr1 a nivel del ret\u00edculo endoplasm\u00e1tico y contribuye a retener a ksr1 y mek en complejos multiproteicos de elevado peso molecular. Adem\u00e1s, hemos demostrado como ksr1 resulta necesaria para la modulaci\u00f3n de la ruta de se\u00f1alizaci\u00f3n de erk por vrk2a.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La quinasa humana vrk2a, un nuevo modulador negativo de la ruta de se\u00f1alizaci\u00f3n de erk1\/2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La quinasa humana vrk2a, un nuevo modulador negativo de la ruta de se\u00f1alizaci\u00f3n de erk1\/2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Fernandez Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/04\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>zbikowski Taracena Lazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jes\u00fas Cruz hern\u00e1ndez <\/li>\n<li>pedro Manuel S\u00e1nchez lazo (vocal)<\/li>\n<li>neus Agell jane (vocal)<\/li>\n<li>Jos\u00e9 Lozano castro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Fernandez Fernandez La familia de serina-treonina quinasas vrk se compone de 3 miembros vrk1, vrk2 y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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