{"id":107789,"date":"2011-05-04T00:00:00","date_gmt":"2011-05-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-marcadores-pronosticos-en-el-linfoma-difuso-de-celula-grande-b-gastrico-expresion-de-protea%c2%adnas-y-metilacion-de-promotores\/"},"modified":"2011-05-04T00:00:00","modified_gmt":"2011-05-04T00:00:00","slug":"nuevos-marcadores-pronosticos-en-el-linfoma-difuso-de-celula-grande-b-gastrico-expresion-de-protea%c2%adnas-y-metilacion-de-promotores","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hemopatologia\/nuevos-marcadores-pronosticos-en-el-linfoma-difuso-de-celula-grande-b-gastrico-expresion-de-protea%c2%adnas-y-metilacion-de-promotores\/","title":{"rendered":"Nuevos marcadores pron\u00f3sticos en el linfoma difuso de c\u00e9lula grande b g\u00e1strico: expresi\u00f3n de prote\u00ednas y metilaci\u00f3n de promotores"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Maialen Martin Arruti <\/strong><\/h2>\n<p>El linfoma difuso de c\u00e9lula grande b (dlbcl), es el tipo m\u00e1s frecuentes de linfomas no-hodgkin. Su localizaci\u00f3n extranodal m\u00e1s frecuente es la g\u00e1strica. El pron\u00f3stico de los dlbcl g\u00e1stricos es variable. Sin embargo, no se disponen de factores pron\u00f3sicos que puedan predecir la evoluci\u00f3n de los pacientes y as\u00ed estableces la terapia m\u00e1s adecuada para cada uno. Por ello, en este trabajo hemos analizado la asociaci\u00f3n con la supervivencia de par\u00e1metros cl\u00ednicos, expresi\u00f3n de prote\u00ednas y metilaci\u00f3n de promotores, que han sido propuestos como marcadores pron\u00f3sticos en dlbcls de otras localizaciones. Por otro lado, ya que se ha propuesto que la metilaci\u00f3n de promotores en genes en c\u00e9lulas g\u00e1stricas podr\u00eda dar lugar al c\u00e1ncer g\u00e1strico y que esta metilaci\u00f3n podr\u00eda estar causada por la infecci\u00f3n por la bacteria h. Pylori, hemos analizado el papel de esta bacteria en la metilaci\u00f3n de promotores y en la oncog\u00e9nesis del dlbcl g\u00e1strico.   entre los marcadores analizados, la expresi\u00f3n de la prote\u00edna blimp-1 ha sido la que mejor ha clasificado a los pacientes con un mal pron\u00f3stico. Por otro lado, hemos observado que la metilaci\u00f3n de promotores de genes espec\u00edficos est\u00e1 implicada en la oncog\u00e9nesis del dlbcl g\u00e1strico y que esta metilaci\u00f3n podr\u00eda estar causada por h. Pylori en etapas preneopl\u00e1sicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos marcadores pron\u00f3sticos en el linfoma difuso de c\u00e9lula grande b g\u00e1strico: expresi\u00f3n de prote\u00ednas y metilaci\u00f3n de promotores<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos marcadores pron\u00f3sticos en el linfoma difuso de c\u00e9lula grande b g\u00e1strico: expresi\u00f3n de prote\u00ednas y metilaci\u00f3n de promotores <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Maialen Martin Arruti <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/04\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Africa Garcia Orad<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  de los angeles Martinez de pancorbo gomez <\/li>\n<li>Juan  Fernando Garcia garcia (vocal)<\/li>\n<li>Mar\u00eda  rosa Caball\u00edn fern\u00e1ndez (vocal)<\/li>\n<li>isabel Guerra merino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Maialen Martin Arruti El linfoma difuso de c\u00e9lula grande b (dlbcl), es el tipo m\u00e1s frecuentes de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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