{"id":107825,"date":"2011-07-04T00:00:00","date_gmt":"2011-07-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-proteomico-del-nucleo-accumbens-y-la-corteza-prefrontal-de-ratas-con-distinta-vulnerabilidad-a-la-adiccion-a-cocaa%c2%adna-y-morfina\/"},"modified":"2011-07-04T00:00:00","modified_gmt":"2011-07-04T00:00:00","slug":"estudio-proteomico-del-nucleo-accumbens-y-la-corteza-prefrontal-de-ratas-con-distinta-vulnerabilidad-a-la-adiccion-a-cocaa%c2%adna-y-morfina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/comportamiento-animal\/estudio-proteomico-del-nucleo-accumbens-y-la-corteza-prefrontal-de-ratas-con-distinta-vulnerabilidad-a-la-adiccion-a-cocaa%c2%adna-y-morfina\/","title":{"rendered":"Estudio prote\u00f3mico del n\u00facleo accumbens y la corteza prefrontal de ratas con distinta vulnerabilidad a la adicci\u00f3n a coca\u00edna y morfina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Del Castillo Aguado <\/strong><\/h2>\n<p>La vulnerabilidad a los efectos de las sustancias adictivas es uno de los aspectos clave en el estudio de las drogodependencias, ya que los mecanismos por los que se desarrolla la adicci\u00f3n hasta el momento no son muy conocidos.   para profundizar en su conocimiento,  los modelos de animales que muestran diferente susceptibilidad a las drogas de abuso proporcionan una herramienta \u00fatil para su estudio. Para ello, se utiliz\u00f3 el test de extinci\u00f3n del condicionamiento preferencial al sitio inducido por drogas (coca\u00edna y morfina para la realizaci\u00f3n de esta tesis), el cual permite seleccionar animales con distinta vulnerabilidad a los efectos de la drogas de abuso. Adem\u00e1s se utilizaron ratas fischer 344 y lewis que muestran diferencias cong\u00e9nitas en su susceptibilidad a las sustancias adictivas. Con el fin de encontrar biomarcadores de vulnerabilidad en dichos modelos se emplearon t\u00e9cnicas de prote\u00f3mica, en concreto, la electroforesis bidimensional, la cual permite alcanzar una visi\u00f3n global de los procesos que pueden verse modificados por las diferencias en la respuesta a las drogas.   en nuestros resultados hemos encontrado alteraciones en la expresi\u00f3n de prote\u00ednas implicadas en procesos biol\u00f3gicos de suma importancia como la fosforilaci\u00f3n oxidativa, el ciclo de krebs o la organizaci\u00f3n y ensamblaje celular, entre otros. Estas prote\u00ednas, tras ser validadas por estudios comportamentales, se podr\u00edan considerar marcadores biol\u00f3gicos de la diferente vulnerabilidad a los efectos de la coca\u00edna y la morfina, as\u00ed como en un futuro podr\u00edan emplearse como posibles dianas terap\u00e9uticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio prote\u00f3mico del n\u00facleo accumbens y la corteza prefrontal de ratas con distinta vulnerabilidad a la adicci\u00f3n a coca\u00edna y morfina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio prote\u00f3mico del n\u00facleo accumbens y la corteza prefrontal de ratas con distinta vulnerabilidad a la adicci\u00f3n a coca\u00edna y morfina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Del Castillo Aguado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 San pablo-ceu<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/04\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lidia Morales Goyanes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis fernando Alguacil merino <\/li>\n<li>david Andreu mart\u00ednez (vocal)<\/li>\n<li>Emilio Ambrosio flores (vocal)<\/li>\n<li>luc\u00eda Monteoliva d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Del Castillo Aguado La vulnerabilidad a los efectos de las sustancias adictivas es uno de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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