{"id":108035,"date":"2018-03-11T10:32:38","date_gmt":"2018-03-11T10:32:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-respuesta-inflamatoria-inducida-por-acidos-grasos-en-macrofagos-papel-de-la-lipina-2\/"},"modified":"2018-03-11T10:32:38","modified_gmt":"2018-03-11T10:32:38","slug":"regulacion-de-la-respuesta-inflamatoria-inducida-por-acidos-grasos-en-macrofagos-papel-de-la-lipina-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/valladolid\/regulacion-de-la-respuesta-inflamatoria-inducida-por-acidos-grasos-en-macrofagos-papel-de-la-lipina-2\/","title":{"rendered":"Regulaci\u00f3n de la respuesta inflamatoria inducida por \u00e1cidos grasos en macr\u00f3fagos: papel de la lipina-2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mart\u00edn Valdearcos Contreras <\/strong><\/h2>\n<p>Durante las \u00faltimas d\u00e9cadas, la obesidad se ha incrementado a proporciones epid\u00e9micas, expecialmente en paises desarrollados, siendo particularmente alarmante en la poblaci\u00f3n infantil. La obesidad lleva asociado un abanico de patolog\u00edas metab\u00f3licas que incluyen la diabetes mellitus tipo 2 y diferentes enfermedades cardiovasculares, que hn motivoado la investigaci\u00f3n dedicada a esclarecer los mecanismos que las desencadenan. Muchos trabajos recientes de investigaci\u00f3n sugiere que existe una gran conexi\u00f3n entre la situaci\u00f3n nutricional o metab\u00f3lica y la respuesta inmunol\u00f3gica. La obesidad se caracteriza por un estado de inflamaci\u00f3n cr\u00f3nica de bajo grado debido a una producci\u00f3n an\u00f3mala de citoquinas proinflamatorias promovida en gran parte, por la infiltraci\u00f3n de macr\u00f3fagos en el tejido adiposo. La presenta memoria de tesis se centra en el estudio del papel de ciertas prote\u00ednas se\u00f1alizadoras y a la vez involucradas en el almacenamiento lip\u00eddico, las lipinas, y m\u00e1s concretamente, la lipina-2, en la modulaci\u00f3n de la respuesta inmune en un contexto de alta disponibilidad de \u00e1cidos grasos, especialmente \u00e1cidos grasos saturados, que es caracter\u00edstico de los estados de obesidad. En la activaci\u00f3n de la respuesta inflamatoria inducida por \u00e1cidos grasos est\u00e1n implicados receptores tipo toll y varios procesos como la activaci\u00f3n del factor de transcripci\u00f3n nf-kb, estr\u00e9s de ret\u00edculo endopl\u00e1smico y la activaci\u00f3n de las map quinasas, especialmente jnk1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la respuesta inflamatoria inducida por \u00e1cidos grasos en macr\u00f3fagos: papel de la lipina-2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la respuesta inflamatoria inducida por \u00e1cidos grasos en macr\u00f3fagos: papel de la lipina-2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mart\u00edn Valdearcos Contreras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Angeles Balboa Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Gomez mu\u00f1oz <\/li>\n<li>\u00e1ngela Mar\u00eda Mart\u00ednez valverde (vocal)<\/li>\n<li>m. carmen Garc\u00eda ruiz (vocal)<\/li>\n<li>manel Vazquez carrera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00edn Valdearcos Contreras Durante las \u00faltimas d\u00e9cadas, la obesidad se ha incrementado a proporciones epid\u00e9micas, expecialmente en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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