{"id":108167,"date":"2018-03-11T10:32:52","date_gmt":"2018-03-11T10:32:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/datos-cla%c2%adnico-biologicos-que-permiten-subclasificar-a-los-pacientes-con-sa%c2%adndrome-mielodisplasico-en-nuevos-grupos-de-riesgo\/"},"modified":"2018-03-11T10:32:52","modified_gmt":"2018-03-11T10:32:52","slug":"datos-cla%c2%adnico-biologicos-que-permiten-subclasificar-a-los-pacientes-con-sa%c2%adndrome-mielodisplasico-en-nuevos-grupos-de-riesgo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hemopatologia\/datos-cla%c2%adnico-biologicos-que-permiten-subclasificar-a-los-pacientes-con-sa%c2%adndrome-mielodisplasico-en-nuevos-grupos-de-riesgo\/","title":{"rendered":"Datos cl\u00ednico-biol\u00f3gicos que permiten subclasificar a los pacientes con s\u00edndrome mielodispl\u00e1sico en nuevos grupos de riesgo"},"content":{"rendered":"

Tesis doctoral de Iris Faritza C\u00f3rdoba Franco <\/strong><\/h2>\n

Las herramientas pron\u00f3sticas m\u00e1s utilizadas en la actualidad, como el ipss o el wpss, tienen varias limitaciones. No consideran el tipo, ni la severidad de las citopenias y se da muy poco peso pron\u00f3stico a las alteraciones citogen\u00e9ticas. nuestra hip\u00f3tesis es que existen datos cl\u00ednico-biol\u00f3gicos f\u00e1ciles de obtener al diagn\u00f3stico que a\u00f1aden valor pron\u00f3stico al ipss. analizamos el impacto de la severidad de la trombocitopenia (<30x109\/l)\/neutropenia (<0.5x109\/l) en 2.565 pacientes incluidos en registro espa\u00f1ol de smd. la trombocitopenia grave (incidencia 7.1%), se asoci\u00f3 con los subtipos oms e ipss de alto riesgo. Adem\u00e1s, predijo un impacto negativo en la sg de los smd ipss bajo\/intermedio-1 (sg 19 meses vs. 64 meses, p<0.0001). La supervivencia acortada en smd bajo riesgo y plaquetas <30x109\/l fue debida a un riesgo aumentado de hemorragia. de forma similar la neutropenia grave (incidencia 12.5%), se asoci\u00f3 con una supervivencia acortada y aumento del riesgo de transformaci\u00f3n a lma en smd ipss bajo\/intermedio-1. en una segunda parte analizamos las diferencias cl\u00ednico-pron\u00f3sticas entre smd y del(7q) frente a smd y monosom\u00eda 7. el subtipo citogen\u00e9tico smd y del(7q) aislada present\u00f3 caracter\u00edsticas cl\u00ednico-biol\u00f3gicas distintas (menos blastos, menos trombocitopenia y neutropenia, subtipos oms de bajo riesgo, etc.) Y mejor supervivencia con respecto a los pacientes con monosom\u00eda 7 (41 meses vs. 16 meses, p=0.011). conclusiones: la severidad de la trombocitopenia y la neutropenia y el tipo de alteraci\u00f3n en el cromosoma 7, a\u00f1aden valor pron\u00f3stico al ipss.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abDatos cl\u00ednico-biol\u00f3gicos que permiten subclasificar a los pacientes con s\u00edndrome mielodispl\u00e1sico en nuevos grupos de riesgo<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Datos cl\u00ednico-biol\u00f3gicos que permiten subclasificar a los pacientes con s\u00edndrome mielodispl\u00e1sico en nuevos grupos de riesgo <\/li>\n
  • Autor:<\/strong>\u00a0 Iris Faritza C\u00f3rdoba Franco <\/li>\n
  • Universidad:<\/strong>\u00a0 Salamanca<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 29\/04\/2011<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Mar\u00eda Consuelo Juan a Del Ca\u00f1izo Fernandez Roldan<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Jes\u00fas fernando San Miguel izquierdo <\/li>\n
        • lourdes Florensa brichs (vocal)<\/li>\n
        • Ana Villegas mart\u00ednez (vocal)<\/li>\n
        • Fernando Ramos ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Iris Faritza C\u00f3rdoba Franco Las herramientas pron\u00f3sticas m\u00e1s utilizadas en la actualidad, como el ipss o el […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[218,195,9386],"tags":[9707,61336,216938,9596,142887,9401],"class_list":["post-108167","post","type-post","status-publish","format-standard","hentry","category-hematologia","category-hemopatologia","category-salamanca","tag-ana-villegas-Martinez","tag-fernando-ramos-ortega","tag-iris-faritza-cordoba-franco","tag-jesus-fernando-san-miguel-izquierdo","tag-lourdes-florensa-brichs","tag-maria-consuelo-juan-a-del-canizo-fernandez-roldan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/108167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=108167"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/108167\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=108167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=108167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=108167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}