{"id":108169,"date":"2018-03-11T10:32:52","date_gmt":"2018-03-11T10:32:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/acetiltransferasas-de-histonas-en-candida-albicans-analisis-del-perfil-transcripcional\/"},"modified":"2018-03-11T10:32:52","modified_gmt":"2018-03-11T10:32:52","slug":"acetiltransferasas-de-histonas-en-candida-albicans-analisis-del-perfil-transcripcional","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia\/acetiltransferasas-de-histonas-en-candida-albicans-analisis-del-perfil-transcripcional\/","title":{"rendered":"Acetiltransferasas de histonas en candida albicans: an\u00e1lisis del perfil transcripcional"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Mar\u00eda D\u00e9gano Bl\u00e1zquez <\/strong><\/h2>\n<p>Candida albicans es un hongo pat\u00f3geno oportunista en humanos. Las infecciones causadas por c. Albicans dependen de varios factores de virulencia, destacando su alto grado de polimorfismo. El cambio morfol\u00f3gico, depende de cambios muy regulados en el interior del n\u00facleo celular donde el dna de todos los cromosomas se encuentra empaquetado formando la cromatina. Los extremos n-terminales de las histonas sufren modificaciones post-traduccionales, como la acetilaci\u00f3n reversible de residuos de lisina, que altera la uni\u00f3n con el dna creando estructuras abiertas que facilitan los procesos transcripcionales. Las acetiltransferasas de histonas son las responsables de esta modificaci\u00f3n. Forman complejos multiproteicos multifuncionales. Actualmente en funci\u00f3n del sustrato y la subunidad catal\u00edtica las dos familias principales son gnat (que incluye gcn5 y hat1) y myst. Se han delecionado los genes gcn5 y hat1 que codifican acetiltransferasas de histonas en c. Albicans y el regulador hat2 empleando la t\u00e9cnica ura-blaster. El an\u00e1lisis fenot\u00edpico muestra que los mutantes gcn5 forman pseudohifas y son incapaces de llevar a cabo la filamentaci\u00f3n en medios s\u00f3lidos y l\u00edquidos y no forman clamidosporas. Los mutantes hat1 forman filamentos engrosados y c\u00e9lulas encadenadas, tambi\u00e9n forman clamidosporas. Los mutantes hat2 no muestran fenotipo aparente. En el an\u00e1lisis del perfil transcripcional del mutante hat1 en crecimiento exponencial destaca la sobreexpresi\u00f3n de activadores transcripcionales de la familia tlo y en el mutante gcn5 los procesos de traducci\u00f3n est\u00e1n seriamente afectados. Durante la transici\u00f3n levadura-hifa, en ambos mutantes se sobreexpresan genes que codifican prote\u00ednas relacionadas con la estructura de la pared y la superficie celular. La subexpresion de genes que codifican aspartil proteasas y adesinas entre otros, podr\u00eda explicar la hipovirulencia observada en ambos mutantes, indic\u00e1ndonos adem\u00e1s un papel destacado de las acetiltransferasas de histonas en la capacidad de virulencia, adhesi\u00f3n e interacciones c\u00e9lula-c\u00e9lula de c. Albicans.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acetiltransferasas de histonas en candida albicans: an\u00e1lisis del perfil transcripcional<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acetiltransferasas de histonas en candida albicans: an\u00e1lisis del perfil transcripcional <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Mar\u00eda D\u00e9gano Bl\u00e1zquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/04\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Dom\u00ednguez Olavarri<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tom\u00e1s Gonz\u00e1lez villa <\/li>\n<li>Luis rom\u00e1n Fern\u00e1ndez lago (vocal)<\/li>\n<li>Mar\u00eda  encarnaci\u00f3n Andaluz l\u00f3pez (vocal)<\/li>\n<li>Mar\u00eda dolores Moragues tosantos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Mar\u00eda D\u00e9gano Bl\u00e1zquez Candida albicans es un hongo pat\u00f3geno oportunista en humanos. Las infecciones causadas por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36606,59053,278,9386],"tags":[9537,137552,216943,216942,216941,2553],"class_list":["post-108169","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular-de-microorganismos","category-genetica-molecular-de-levaduras","category-microbiologia","category-salamanca","tag-angel-dominguez-olavarri","tag-luis-roman-fernandez-lago","tag-maria-dolores-moragues-tosantos","tag-maria-encarnacion-andaluz-lopez","tag-rosa-maria-degano-blazquez","tag-tomas-gonzalez-villa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/108169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=108169"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/108169\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=108169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=108169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=108169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}