{"id":108230,"date":"2011-04-05T00:00:00","date_gmt":"2011-04-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cancer-de-pulmon-y-citocinas-variantes-cla%c2%adnicas-y-geneticas\/"},"modified":"2011-04-05T00:00:00","modified_gmt":"2011-04-05T00:00:00","slug":"cancer-de-pulmon-y-citocinas-variantes-cla%c2%adnicas-y-geneticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/enfermedades-pulmonares\/cancer-de-pulmon-y-citocinas-variantes-cla%c2%adnicas-y-geneticas\/","title":{"rendered":"C\u00e1ncer de pulm\u00f3n y citocinas: variantes cl\u00ednicas y gen\u00e9ticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Esther Jimenez Massa <\/strong><\/h2>\n<p>El c\u00e1ncer de pulm\u00f3n es desde hace a\u00f1os el tumor diagnosticado con mayor frecuencia en los pa\u00edses industrializados y tambi\u00e9n el que origina mayor n\u00famero de muertes. Sin ambargo, los eventos espec\u00edficos que conducen a la transformaci\u00f3n maligna de las c\u00e9lulas broncoepiteliales son desconocidos.  el humo del tabaco, principal agente causal de esta patolog\u00eda, ocasiona la inflamaci\u00f3n del tracto respiratorio, contribuyendo al estr\u00e9s oxidativo que favorece la aparici\u00f3n y progresi\u00f3n del c\u00e1ncer. La enfermedad pulmonar obstructiva cr\u00f3nica (epoc), con etiolog\u00eda com\u00fan, tambi\u00e9n ha demostrado su asociaci\u00f3n con el c\u00e1ncer de pulm\u00f3n., Aumentando el riesgo hasta cinco veces en los que tienen esta enfermedad. Esto es debido a que el humo del tabaco promueve la expresi\u00f3n de ciertas citocinas, entre ellas la il-6, il-8 e il-10, que pueden actuar inhibiendo la apoptosis celular, interfieren en los mecanismos de reparaci\u00f3n celular y promueven la angiog\u00e9nesis.  este trabajo estableci\u00f3 como objetivo principal analizar la posible relaci\u00f3n del c\u00e1ncer de pulm\u00f3n y los polimorfismos de los genes que codifican las interleucinas a estudio, as\u00ed como conocer el perfil epidemiol\u00f3gico y cl\u00ednico de los pacientes con c\u00e1ncer.  se dise\u00f1\u00ed\u00a7o un estudio de casos y controles en el que se incluyeron 200 pacientes en cada grupo. El tama\u00f1o de la muestra garantiza una representatividad de la poblaci\u00f3n a la que pertenece.  tras la extracci\u00f3n y purificaci\u00f3n del adn a partir de las c\u00e9lulas nucleadas de sangre perif\u00e9rica se procedi\u00f3 a la discriminaci\u00f3n al\u00e9lica mediante procedimientos distintos, dependiendo de la interleucina a estudio, bien por pcr con sondas taqman o mediante digesti\u00f3n con nucleasas de restricci\u00f3n.  concluimos que los polimorfismos incluidos en este estudio no modifican el riesgo de desarrollar c\u00e1ncer de pulm\u00f3n. Sin embargo, los continuos esfuerzos por descifrar el genoma del c\u00e1ncer sugieren un futuro prometedor para el manejo cl\u00ednico de esta patolog\u00eda.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>C\u00e1ncer de pulm\u00f3n y citocinas: variantes cl\u00ednicas y gen\u00e9ticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 C\u00e1ncer de pulm\u00f3n y citocinas: variantes cl\u00ednicas y gen\u00e9ticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Esther Jimenez Massa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/05\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Montserrat Alonso Sardon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Antonio Alvarez-sala walther <\/li>\n<li>miriam Zeini moreno (vocal)<\/li>\n<li>Jos\u00e9 Antonio Mir\u00f3n canelo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Esther Jimenez Massa El c\u00e1ncer de pulm\u00f3n es desde hace a\u00f1os el tumor diagnosticado con mayor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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