{"id":108302,"date":"2011-06-05T00:00:00","date_gmt":"2011-06-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-cla%c2%adnico-y-molecular-de-acalasia-esofagica\/"},"modified":"2011-06-05T00:00:00","modified_gmt":"2011-06-05T00:00:00","slug":"estudio-cla%c2%adnico-y-molecular-de-acalasia-esofagica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/estudio-cla%c2%adnico-y-molecular-de-acalasia-esofagica\/","title":{"rendered":"Estudio cl\u00ednico y molecular de acalasia esof\u00e1gica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Auxiliadora Tejedor Cerde\u00f1a <\/strong><\/h2>\n<p>La acalasia es una enfermedad de etiolog\u00eda desconocida que se caracteriza por la presencia de un infiltrado inflamatorio de linfocitos t, fundamentalmente cd3 y cd8, y se ha planteado este estudio con el objetivo de conocer la evoluci\u00f3n de los pacientes seg\u00fan el tratamiento recibido, comparando la eficacia de los diferentes tratamientos, y de establecer la implicaci\u00f3n de citocinas proinflamatorias (il-6, il-4, tnf\u00c2\u00bf), la sintasa del \u00f3xido n\u00edtrico, la endotelina 1 y el ppar\u00c2\u00bf en la etiopatog\u00e9nesis de la acalasia. nuestros resultados mostraron que la inyecci\u00f3n de toxina botul\u00ednica era un tratamiento \u00fatil y seguro en pacientes de edad avanzada y con comorbilidades, siendo la dilataci\u00f3n neum\u00e1tica un tratamiento efectivo para el control de los s\u00edntomas, aunque, en ocasiones, precis\u00f3 de varias sesiones para lograr la remisi\u00f3n cl\u00ednica. Sin embargo, en nuestra serie, la cirug\u00eda fue el mejor tratamiento para conseguir la remisi\u00f3n cl\u00ednica y, aunque la dilataci\u00f3n y la cirug\u00eda redujeron de forma significativa la presi\u00f3n del eei, no observamos la superioridad de una t\u00e9cnica respecto a la otra. en las exploraciones con tr\u00e1nsito baritado se observ\u00f3 una reducci\u00f3n del di\u00e1metro del cuerpo esof\u00e1gico y un aumento del di\u00e1metro del cardias tras la dilataci\u00f3n y la cirug\u00eda, siendo mayor el aumento del di\u00e1metro del cardias tras la cirug\u00eda.  por \u00faltimo, el estudio de variantes gen\u00e9ticas mostr\u00f3 que los portadores del alelo c del polimorfismo de il-4 -33c\/t, as\u00ed como aquellos portadores del genotipo ct del polimorfismo de nos3 -786c\/t, estaban m\u00e1s representados en el grupo diagnosticado de acalasia esof\u00e1gica, al contrario que en el caso de los portadores del alelo t del primer polimorfismo y del genotipo cc del segundo. Estos resultados sugieren que pueden existir factores gen\u00e9ticos que modifican la susceptibilidad a desarrollar la enfermedad, siendo necesarios estudios en series m\u00e1s amplias para confirmar esta hip\u00f3tesis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio cl\u00ednico y molecular de acalasia esof\u00e1gica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio cl\u00ednico y molecular de acalasia esof\u00e1gica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Auxiliadora Tejedor Cerde\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/05\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rogelio Gonzalez Sarmiento<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Sanchez rodriguez <\/li>\n<li>sabino Riestra  men\u00e9ndez (vocal)<\/li>\n<li>agustin Caro paton gomez (vocal)<\/li>\n<li>Jos\u00e9 Luis Olcoz go\u00f1i (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Auxiliadora Tejedor Cerde\u00f1a La acalasia es una enfermedad de etiolog\u00eda desconocida que se caracteriza por la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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