{"id":108310,"date":"2011-06-05T00:00:00","date_gmt":"2011-06-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-alfa1-adrenergica-de-la-corriente-ikr-cardiaca\/"},"modified":"2011-06-05T00:00:00","modified_gmt":"2011-06-05T00:00:00","slug":"regulacion-alfa1-adrenergica-de-la-corriente-ikr-cardiaca","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-humana\/regulacion-alfa1-adrenergica-de-la-corriente-ikr-cardiaca\/","title":{"rendered":"Regulaci\u00f3n alfa1-adren\u00e9rgica de la corriente ikr cardiaca"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Janire Urrutia I\u00f1iguez <\/strong><\/h2>\n<p>Las distintas demandas cardiovasculares del coraz\u00f3n requieren respuestas din\u00e1micas. el ritmo cardiaco y la contractilidad son regulados por complejos hormonales y cascadas de se\u00f1alizaci\u00f3n aut\u00f3nomas implicando receptores acoplados a prote\u00ednas g. en particular la estimulaci\u00f3n de \u00c2\u00bf1-ar en cardiomiocitos provoca un alargamiento en la repolarizaci\u00f3n, un aumento moderado del inotropismo y un descenso del automatismo de las c\u00e9lulas de purkinje [kurz et \u00e1l., 1991], particularmente durante periodos de estr\u00e9s extremo o una estimulaci\u00f3n aut\u00f3noma. Bajo condiciones patofisiol\u00f3gicas, resultados mal-adaptativos pueden inducir eventos severos cardiovasculares. As\u00ed, las arritmias ventriculares son a menudo precipitadas por estr\u00e9s f\u00edsico o emocional en particular en enfermos coronarios o con lqts [lown, 1987; kamarck &#038; jennings, 1991; napolitano et \u00e1l., 1994; priori et \u00e1l., 1997]. los resultados obtenidos en este trabajo, indican que la regulaci\u00f3n de la corriente herg por el receptor \u00c2\u00bf1a-ar est\u00e1 mediada por la interacci\u00f3n entre pip2 y el canal, con lo cual la disminuci\u00f3n de la concentraci\u00f3n de pip2 desplaza el vh de activaci\u00f3n del canal herg. Adem\u00e1s, el vh de activaci\u00f3n de la corriente herg est\u00e1 desplazado tambi\u00e9n, aunque en menor medida por la activaci\u00f3n de pkc [figura 73]. Este desplazamiento del vh de activaci\u00f3n hacia potenciales m\u00e1s positivos, reduce la disponibilidad de la corriente a potenciales fisiol\u00f3gicos, provocando el alargamiento de la duraci\u00f3n del potencial de acci\u00f3n cardiaco.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n alfa1-adren\u00e9rgica de la corriente ikr cardiaca<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n alfa1-adren\u00e9rgica de la corriente ikr cardiaca <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Janire Urrutia I\u00f1iguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/05\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Monica Gallego Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jon Irazusta astiazaran <\/li>\n<li>carmen Delgado canencia (vocal)<\/li>\n<li>Jes\u00fas Hernandez cascales (vocal)<\/li>\n<li>pilar De la pe\u00f1a cortines (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Janire Urrutia I\u00f1iguez Las distintas demandas cardiovasculares del coraz\u00f3n requieren respuestas din\u00e1micas. el ritmo cardiaco y la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[932,5793,817,12909],"tags":[23437,217161,3171,72633,61842,94089],"class_list":["post-108310","post","type-post","status-publish","format-standard","hentry","category-cardiologia","category-fisiologia-cardiovascular","category-fisiologia-humana","category-pais-vasco-euskal-herriko-unibertsitatea","tag-carmen-delgado-canencia","tag-janire-urrutia-iniguez","tag-jesus-hernandez-cascales","tag-jon-irazusta-astiazaran","tag-monica-gallego-munoz","tag-pilar-de-la-pena-cortines"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/108310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=108310"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/108310\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=108310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=108310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=108310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}