{"id":108392,"date":"2018-03-11T10:33:09","date_gmt":"2018-03-11T10:33:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-geneticos-de-susceptibilidad-a-enfermedad-inflamatoria-intestinal-en-la-poblacion-espanola\/"},"modified":"2018-03-11T10:33:09","modified_gmt":"2018-03-11T10:33:09","slug":"factores-geneticos-de-susceptibilidad-a-enfermedad-inflamatoria-intestinal-en-la-poblacion-espanola","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/factores-geneticos-de-susceptibilidad-a-enfermedad-inflamatoria-intestinal-en-la-poblacion-espanola\/","title":{"rendered":"Factores gen\u00e9ticos de susceptibilidad a enfermedad inflamatoria intestinal en la poblaci\u00f3n espa\u00f1ola"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Mar\u00eda M\u00e1rquez Ortiz <\/strong><\/h2>\n<p>La enfermedad inflamatoria intestinal (eii) es una inflamaci\u00f3n cr\u00f3nica del tracto gastrointestinal de etiolog\u00eda desconocida. Se clasifica en dos formas, enfermedad de crohn (ec) y colitis ulcerosa (cu), que se consideran enfermedades diferentes pero comparten caracter\u00edsticas cl\u00ednicas, factores gen\u00e9ticos y aspectos inmunol\u00f3gicos. la eii se caracteriza por ser una enfermedad compleja multifactorial, en la que est\u00e1n implicados tanto factores gen\u00e9ticos como ambientales. Aunque en los \u00faltimos a\u00f1os se  ha avanzado considerablemente en el conocimiento de la base gen\u00e9tica de esta patolog\u00eda, fundamentalmente gracias a los estudios de asociaci\u00f3n mediante barrido gen\u00f3mico (gwas, \u00c2\u00bfgenome wide association studies\u00c2\u00bf), las regiones de susceptibilidad identi ficadas hasta la fecha, 71 en el caso de la enfermedad de crohn y 30 en el caso de la colitis ulcerosa, no explican completamente el componente hereditario de la eii, por lo que deben existir m\u00e1s genes, as\u00ed como interacciones gen-gen y gen-ambiente, implicados en la patolog\u00eda. Algunos de los factores de susceptibilidad descritos son espec\u00edficos de la ec o la cu, mientras que otros son compartidos por ambas y, muchos de ellos, est\u00e1n implicados en otras enfermedades de car\u00e1cter autoinmune indicand o mecanismos moleculares comunes entre ellas. el objetivo de este trabajo es la b\u00fasqueda de nuevos factores gen\u00e9ticos que contribuyan a la susceptibilidad a padecer eii, mediante estudios de asociaci\u00f3n caso-control y el an\u00e1lisis de interacciones entr e genes. Para ello analizamos polimorfismos de un solo nucle\u00f3tido (snps, \u00c2\u00bfsingle nucleotide polymorphisms\u00c2\u00bf), previamente asociados a la eii y\/o a otras enfermedades autoinmunes, localizados en genes que por su funci\u00f3n podr\u00edan desempe\u00f1ar un papel en l a patolog\u00eda. Concretamente, analizamos genes que codifican receptores de patrones moleculares asociados a pat\u00f3genos (ifih1 y clec16a), genes implicados en autofagia (irgm y atg16l1), genes que codifican citoquinas y receptores de citoquinas (mst1, il 2, il2ra, il2rb, il23r, il12b) y genes que codifican factores de transcripci\u00f3n (nkx2-3, pxr, stat4 y stat3).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores gen\u00e9ticos de susceptibilidad a enfermedad inflamatoria intestinal en la poblaci\u00f3n espa\u00f1ola<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores gen\u00e9ticos de susceptibilidad a enfermedad inflamatoria intestinal en la poblaci\u00f3n espa\u00f1ola <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Mar\u00eda M\u00e1rquez Ortiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/05\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Urcelay Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: almudena Porras gallo <\/li>\n<li>Mar\u00eda dolores P\u00e9rez-sala gozalo (vocal)<\/li>\n<li>Mar\u00eda  isabel Vera mendoza (vocal)<\/li>\n<li>nora viviana Butta coll (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Mar\u00eda M\u00e1rquez Ortiz La enfermedad inflamatoria intestinal (eii) es una inflamaci\u00f3n cr\u00f3nica del tracto gastrointestinal de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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