{"id":108564,"date":"2018-03-11T10:33:24","date_gmt":"2018-03-11T10:33:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-actividad-antioncogenica-de-nur77\/"},"modified":"2018-03-11T10:33:24","modified_gmt":"2018-03-11T10:33:24","slug":"estudio-de-la-actividad-antioncogenica-de-nur77","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/estudio-de-la-actividad-antioncogenica-de-nur77\/","title":{"rendered":"Estudio de la actividad antioncog\u00e9nica de nur77"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Dolores Sanguinetti Rodr\u00edguez <\/strong><\/h2>\n<p>Nur77 es un factor de transcripci\u00f3n que pertenece a la superfamilia de receptores nucleares esteroideos. Se trata de un gen de respuesta tempranainmediata inducido por una gran variedad de est\u00edmulos extracelulares, como los est\u00edmulos de supervivencia, diferenciaci\u00f3n o de apoptosis. Recientemente, se demostr\u00f3 una interacci\u00f3n f\u00edsica entre nur77 y el supresor de tumores p53, la cual ser\u00eda necesaria para la estabilizaci\u00f3n de p53, se demuestra tambi\u00e9n que nur77 favorece la apoptosis dependiente de p53 inducida por radiaci\u00f3n ultravioleta. Estos datos sugieren que nur77 podr\u00eda mediar las acciones proapopt\u00f3ticas de p53. La capacidad de nur77 para inducir muerte celular en c\u00e9lulas cancerosas lo convierten en una mol\u00e9cula de inter\u00e9s terap\u00e9utico. El estudio contempla: 1. Estudiar la regulaci\u00f3n de los niveles de nur77. utilizaremos modelos celulares y estudiaremos posibles cambios a nivel de mrna y de prote\u00edna, analizando posibles rutas que podr\u00edan estar implicadas, como la ruta de rb o la de p53. 2. Evaluar la acci\u00f3n antioncog\u00e9nica de nur77. se realizar\u00e1n dos aproximaciones; a) estudio invitro utilizando modelos celulares, b) estudio in vivo, utilizando diferentes modelos de ratones modificados gen\u00e9ticamente. 3. Estudiar la expresi\u00f3n de nur77 en tumores humanos, estudiaremos su expresi\u00f3n en cohortes de tumores humanos y sus correspondientes muestras de tejido normal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la actividad antioncog\u00e9nica de nur77<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la actividad antioncog\u00e9nica de nur77 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Dolores Sanguinetti Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Carmen Carneiro  Freire<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Dominguez puente <\/li>\n<li>joan Seoane suarez (vocal)<\/li>\n<li>Manuel Collado rodr\u00edguez (vocal)<\/li>\n<li>purificaci\u00f3n Mu\u00f1oz moruno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dolores Sanguinetti Rodr\u00edguez Nur77 es un factor de transcripci\u00f3n que pertenece a la superfamilia de receptores nucleares [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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