{"id":108811,"date":"2011-01-06T00:00:00","date_gmt":"2011-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sa%c2%adntesis-y-desarrollo-de-ligandos-marcados-para-el-estudio-de-los-receptores-de-cannabinoides-cb1-y-cb2\/"},"modified":"2011-01-06T00:00:00","modified_gmt":"2011-01-06T00:00:00","slug":"diseno-sa%c2%adntesis-y-desarrollo-de-ligandos-marcados-para-el-estudio-de-los-receptores-de-cannabinoides-cb1-y-cb2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/diseno-sa%c2%adntesis-y-desarrollo-de-ligandos-marcados-para-el-estudio-de-los-receptores-de-cannabinoides-cb1-y-cb2\/","title":{"rendered":"Dise\u00f1o, s\u00edntesis y desarrollo de ligandos marcados para el estudio de los receptores de cannabinoides cb1 y cb2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lidia Martin Couce <\/strong><\/h2>\n<p>En la actualidad, el extraordinario potencial de la prote\u00f3mica funcional como herramienta para el estudio directo del proteoma en sistemas biol\u00f3gicos ha estado restringido al campo de las enzimas. Hasta el momento, no se ha desarrollado ninguna sonda  dirigida al estudio de receptores acoplados a prote\u00ednas g. Entre \u00e9stos, los receptores de cannabinoides (cbrs) est\u00e1n considerados como dianas terap\u00e9uticas de enorme inter\u00e9s por su implicaci\u00f3n en multitud de procesos fisiol\u00f3gicos. En este contexto, e n el presente trabajo se han dise\u00f1ado y sintetizado una serie de sondas qu\u00edmicas dirigidas al estudio de los cbrs. Estos compuestos est\u00e1n basados en los esqueletos estructurales de diversos endocannabinoides y cannabinoides sint\u00e9ticos y presentan dif erentes subunidades de marcaje, tales como biotina, benzofenona o alquino terminal. Varios de los compuestos sintetizados muestran una elevada afinidad por los receptores cb1 y cb2. Entre \u00e9stos, el derivado basado en la estructura del ligando end\u00f3gen o 2-araquidonil gliceril \u00e9ter ha permitido la visualizaci\u00f3n del receptor cb1 en c\u00e9lulas transfectadas. Por otro lado, los compuestos basados en las estructuras de los agonistas sint\u00e9ticos hu210 y hu308 han demostrado su validez para la visualizaci\u00f3n de los receptores cb1 y cb2 en sistemas nativos (neuronas y microgl\u00eda). Finalmente, las sondas duales derivadas de hu210 han sido utilizadas para poner a punto una plataforma prote\u00f3mica dirigida a la identificaci\u00f3n de nuevos sitios uni\u00f3n de ligandos cannabinoides. En conjunto, los compuestos desarrollados en este trabajo representan las primeras sondas qu\u00edmicas dirigidas al estudio de una familia de gpcrs, los cbrs.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, s\u00edntesis y desarrollo de ligandos marcados para el estudio de los receptores de cannabinoides cb1 y cb2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, s\u00edntesis y desarrollo de ligandos marcados para el estudio de los receptores de cannabinoides cb1 y cb2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lidia Martin Couce <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>fontecha Corrales Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: odon Arjona loraque <\/li>\n<li>giovanni Marsicano (vocal)<\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<li>jordi Mestres lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lidia Martin Couce En la actualidad, el extraordinario potencial de la prote\u00f3mica funcional como herramienta para el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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