{"id":108830,"date":"2011-01-06T00:00:00","date_gmt":"2011-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-diferentes-grados-de-alteracion-del-metabolismo-de-la-glucosa-en-la-expresion-de-cd36-en-monocitos-de-pacientes-con-aterosclerosis\/"},"modified":"2011-01-06T00:00:00","modified_gmt":"2011-01-06T00:00:00","slug":"efecto-de-los-diferentes-grados-de-alteracion-del-metabolismo-de-la-glucosa-en-la-expresion-de-cd36-en-monocitos-de-pacientes-con-aterosclerosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/reumatologia\/efecto-de-los-diferentes-grados-de-alteracion-del-metabolismo-de-la-glucosa-en-la-expresion-de-cd36-en-monocitos-de-pacientes-con-aterosclerosis\/","title":{"rendered":"Efecto de los diferentes grados de alteraci\u00f3n del metabolismo de la glucosa en la expresi\u00f3n de cd36 en monocitos de pacientes con aterosclerosis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Dolores L\u00f3pez Carmona <\/strong><\/h2>\n<p>T\u00edtulo de la tesis: efecto de los diferentes grados de alteraci\u00f3n del metabolismo de la glucosa en la expresi\u00f3n de cd36 en monocitos de pacientes con aterosclerosis. resumen: la arteriesclerosis es especialmente severa entre la poblaci\u00f3n diab\u00e9tica. En estadios prediab\u00e9ticos existe un exceso de enfermedad que no es atribuible a otros frcv. El cd36 es un receptor sacavenger del monocito que capta fundamentalmente las ldl oxidadas. Busc\u00e1bamos conocer la expresi\u00f3n del cd36 tanto su mrna como en propte\u00edna (glicada y no glicada) en los estadios iniciales de diabetes. primero se realiz\u00f3 un experimento in vitro monocitos de sujetos sanos se cultivaron (48h), en hiperglucemia extrema (hg) y normoglucemia (ng). La hg origin\u00f3 un pico de expresi\u00f3n muy precoz (4h). En el grupo ng el pico apareci\u00f3 al final del experimento. La prote\u00edna no glicada present\u00f3 un pico de expresi\u00f3n m\u00e1s precoz cuanto m\u00e1s alta fue la concentraci\u00f3n de glucosa, (hg: 16h\/ng: 48h).En cuanto a la prote\u00edna glicada la glucosa inhibe la expresi\u00f3n del receptor pero en diferentes tiempos (hg: 8h\/ng: 48h). seg\u00fan estos resultados en el estudio con pacientes ateroseter\u00f3ticos ( n=22) decicimos eliminar a aquellos sujetos con glucemias de ayuno 2126 mg\/dl. Se dividieron en: 5 ng, 7 predib\u00e9ticos (predm) y 10 diab\u00e9ticos (dm). El mrna del cd36 fue disminuyendo desde los ng a los predm y de ellos a los dm. La prote\u00edna no glicada no se modific\u00f3 en ninguno de los grupos. La protefna glicada aument\u00f3 progresivamente desde los ng a los predm y de estos a los dm (p= 0.03).El desarrollo de diabetes ocasiona un incremento de la expresi\u00f3n de cd36 glicado debido al aumento en el reciclaje del receptor.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de los diferentes grados de alteraci\u00f3n del metabolismo de la glucosa en la expresi\u00f3n de cd36 en monocitos de pacientes con aterosclerosis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de los diferentes grados de alteraci\u00f3n del metabolismo de la glucosa en la expresi\u00f3n de cd36 en monocitos de pacientes con aterosclerosis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Dolores L\u00f3pez Carmona <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo G\u00f3mez Huelgas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Gonz\u00e1lez santos <\/li>\n<li>Carlos San rom\u00e1n ter\u00e1n (vocal)<\/li>\n<li>Francisco Gomez rodriguez (vocal)<\/li>\n<li>Francisco j. Tinahones madue\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Dolores L\u00f3pez Carmona T\u00edtulo de la tesis: efecto de los diferentes grados de alteraci\u00f3n del metabolismo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7834,877],"tags":[217974,1508,75340,217973,2192,77837],"class_list":["post-108830","post","type-post","status-publish","format-standard","hentry","category-malaga","category-reumatologia","tag-carlos-san-roman-teran","tag-francisco-gomez-rodriguez","tag-francisco-j-tinahones-madueno","tag-maria-dolores-lopez-carmona","tag-pedro-gonzalez-santos","tag-ricardo-gomez-huelgas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/108830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=108830"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/108830\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=108830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=108830"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=108830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}