{"id":108910,"date":"2011-03-06T00:00:00","date_gmt":"2011-03-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-papel-regulador-de-la-hlstamina-en-el-metabolismo-de-poliaminas\/"},"modified":"2011-03-06T00:00:00","modified_gmt":"2011-03-06T00:00:00","slug":"estudio-del-papel-regulador-de-la-hlstamina-en-el-metabolismo-de-poliaminas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/procesos-metabolicos\/estudio-del-papel-regulador-de-la-hlstamina-en-el-metabolismo-de-poliaminas\/","title":{"rendered":"Estudio del papel regulador de la hlstamina en el metabolismo de poliaminas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hicham Abrighach <\/strong><\/h2>\n<p>Existen evidencias que sugieren la presencia de una interacci\u00f3n entre los metabolismos de histamina y poliaminas en varios tipos celulares de mam\u00edferos, sin embargo, el contexto metab\u00f3lico complejo en el que \u00e9sta tiene lugar hace que sea dif\u00edcil dilucidar los mecanismos implicados. Los efectos de la histamina se producen tras su uni\u00f3n a receptores espec\u00edficos de histamina, de los cuales se han descrito cuatro diferentes. Por otra parte, la histamina intracelular tambi\u00e9n puede interferir con el metabolismo de poliaminas, ya que hay varias conexiones metab\u00f3licas entre las v\u00edas de s\u00edntesis y la degradaci\u00f3n de ambas aminas. Con el fin de analizar los efectos metab\u00f3licos de la histamina intracelular en el metabolismo de poliaminas, se transfectaron c\u00e9lulas hek293 con diferentes versiones, activas e inactivas, de la h\u00edstidina descarboxilasa humana (enzima responsable de la s\u00edntesis de histamina. En este modelo se han estudiado el efecto de la s\u00edntesis de histamina sobre el metabolismo de poliaminas y otros elementos celulares, asi como los mecanismos subyacentes en su caso. Los resultados indican un efecto regulador de la histamina sobre la expresi\u00f3n post-transcripcional de la ornitina decarboxilasa, y sugieren que este efecto es el principal responsable de la disminuci\u00f3n en la s\u00edntesis de poliaminas. Por otro lado, la s\u00edntesis de histamina provoca un bloqueo parcial de la progresi\u00f3n del ciclo celular, que debe afectar a la tasa de proliferaci\u00f3n celular. Una aproximaci\u00f3n prote\u00f3mlca a los efectos de la histamina en el modelo celular utilizado sugiere la implicaci\u00f3n de la via de la p38mapk.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del papel regulador de la hlstamina en el metabolismo de poliaminas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del papel regulador de la hlstamina en el metabolismo de poliaminas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hicham Abrighach <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/06\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Urdiales Ru\u00edz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Miguel Canovas ramos <\/li>\n<li>lina Mayorga mayorga (vocal)<\/li>\n<li>Miguel angel Medina torres (vocal)<\/li>\n<li>mohcine Bennani  mechita (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hicham Abrighach Existen evidencias que sugieren la presencia de una interacci\u00f3n entre los metabolismos de histamina y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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