{"id":109328,"date":"2018-03-11T10:34:41","date_gmt":"2018-03-11T10:34:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/immunomodulation-and-metabolism-possible-role-of-lactoferrin\/"},"modified":"2018-03-11T10:34:41","modified_gmt":"2018-03-11T10:34:41","slug":"immunomodulation-and-metabolism-possible-role-of-lactoferrin","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/immunomodulation-and-metabolism-possible-role-of-lactoferrin\/","title":{"rendered":"Immunomodulation and metabolism: possible role of lactoferrin"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Mar\u00eda Moreno Navarrete <\/strong><\/h2>\n<p>To gain insight in the relationship between innate immune system and metabolic disease, we aimed to investigate the effects of lactoferrin in obesity-related metabolic disturbances. Circulating lactoferrin concentration was significantly decreased in subjects with altered glucose tolerance (agt) and associated negatively with obesity-related metabolic disturbances. The snps-induced aminoacidic changes in lactoferrin n-terminus region were associated with a low atherogenic lipid profile. Lactoferrin production in neutrophils decreased significatively in aging, chronic low-grade inflammation and type 2 diabetes. In vitro, lactoferrin increased insulin signaling pathway, even under insulin resistance conditions and displayed dual effects on adipogenesis (antiadipogenic in 3t3-l1 and adipogenic in human adipocytes). In conclusion, lactoferrin might play a potential protective role against insulin resistance and obesity related metabolic disturbances.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Immunomodulation and metabolism: possible role of lactoferrin<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Immunomodulation and metabolism: possible role of lactoferrin <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Mar\u00eda Moreno Navarrete <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Girona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>real Lemos Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Zorzano olarte <\/li>\n<li>carmen Carretero romay (vocal)<\/li>\n<li>joan Vendrell ortega (vocal)<\/li>\n<li>Mar\u00eda Vilanova brugu\u00e9s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Mar\u00eda Moreno Navarrete To gain insight in the relationship between innate immune system and metabolic disease, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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