{"id":1094,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/el-grupo-de-genes-de-biosintesis-de-penicilina-de-penicillium-chrysogenum-identificacion-y-analisis-de-la-region-del-genoma-que-contiene-los-genes-pcbab-pcbc-y-pende\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"el-grupo-de-genes-de-biosintesis-de-penicilina-de-penicillium-chrysogenum-identificacion-y-analisis-de-la-region-del-genoma-que-contiene-los-genes-pcbab-pcbc-y-pende","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/el-grupo-de-genes-de-biosintesis-de-penicilina-de-penicillium-chrysogenum-identificacion-y-analisis-de-la-region-del-genoma-que-contiene-los-genes-pcbab-pcbc-y-pende\/","title":{"rendered":"El grupo de genes de biosintesis de penicilina de penicillium chrysogenum. identificacion y analisis de la region del genoma que contiene los genes pcbab, pcbc y pende."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bruno D\u00edez Garc\u00eda <\/strong><\/h2>\n<p>El aislamiento del grupo de genes se logro por hibridacion de una genoteca en plasmidos de penicillium con una sonda correspondiente algen pende el ligamiento de los tres genes pcb ab pcbc y pende se demostro por hibridaciones de \u00abnorthern\u00bb y expresion de los fragmentos clonados en mutantes de p.Chrysccenum y cephalosporium acremonium bloqueados en los diferentes pasos biosinteticos se caracterizaron los puntos de inicio y an detranscripcion para los tres genes la expresion del conjunto pcbc-pen-de permitio obtener incrementos de productividad de penicilina del 40%. La secuencia de nucleotidos del gen pcb ab y de la region intergenica pcb-c pen de mostro que los tres genes estaban en un fragmento de 17 kb dando lugar a un transcrito de 11,5kb para el gen pcbab y otros dos de 1,4 kb para los genes pcbc y pende. La proteina acv sintetasa deducida del gen pcbab estaba formada por 3778 aminoacidos. Su estructura mostro poseer tres modulos de 1100 aminoacidos homologos a encimas activadoras de aminoacidos y sintesis de peptidos y un modulo c-t de 500 aminoacidos homologo atiester-hidroasas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El grupo de genes de biosintesis de penicilina de penicillium chrysogenum. identificacion y analisis de la region del genoma que contiene los genes pcbab, pcbc y pende.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El grupo de genes de biosintesis de penicilina de penicillium chrysogenum. identificacion y analisis de la region del genoma que contiene los genes pcbab, pcbc y pende. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bruno D\u00edez Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Mart\u00edn Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: C\u00e9sar Nombela Cano <\/li>\n<li>Daniel Ram\u00f3n Vidal (vocal)<\/li>\n<li>Paloma Liras Pad\u00edn (vocal)<\/li>\n<li>Santiago Torres Mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bruno D\u00edez Garc\u00eda El aislamiento del grupo de genes se logro por hibridacion de una genoteca en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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