{"id":109447,"date":"2018-03-11T10:34:53","date_gmt":"2018-03-11T10:34:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/busqueda-identificacion-y-validacion-de-biomarcadores-moleculares-de-cancer-de-pulmon-mediante-tecnicas-proteomicas\/"},"modified":"2018-03-11T10:34:53","modified_gmt":"2018-03-11T10:34:53","slug":"busqueda-identificacion-y-validacion-de-biomarcadores-moleculares-de-cancer-de-pulmon-mediante-tecnicas-proteomicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/busqueda-identificacion-y-validacion-de-biomarcadores-moleculares-de-cancer-de-pulmon-mediante-tecnicas-proteomicas\/","title":{"rendered":"B\u00fasqueda, identificaci\u00f3n y validaci\u00f3n de biomarcadores moleculares de c\u00e1ncer de pulm\u00f3n mediante t\u00e9cnicas prote\u00f3micas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Uribarri Ormaza <\/strong><\/h2>\n<p>La falta de m\u00e9todos que permitan una detecci\u00f3n temprana del c\u00e1ncer de pulm\u00f3n ha provocado que esta enfermedad sea, hoy en d\u00eda, la causante del mayor n\u00famero de muertes por c\u00e1ncer en todo el mundo. As\u00ed, el principal objetivo planteado en esta tesis fue la b\u00fasqueda de prote\u00ednas espec\u00edficas diferencialmente expresadas en el lavadoaspirado bronquial (lab) de pacientes con neoplasia pulmonar. La cuantificaci\u00f3n de estos biomarcadores en biofluidos obtenidos de manera m\u00ednimamente invasiva para el paciente, ser\u00eda de gran utilidad como complemento a las t\u00e9cnicas de diagn\u00f3stico actuales. con este fin, se emplearon dos t\u00e9cnicas prote\u00f3micas complementarias: la electroforesis bidimensional combinada con la espectrometr\u00eda de masas, durante la fase inicial de b\u00fasqueda e identificaci\u00f3n de biomarcadores, y los inmunoensayos en suspensi\u00f3n para la posterior validaci\u00f3n de los mismos. se encontraron 32 prote\u00ednas con expresi\u00f3n diferencial en los proteomas del lab de pacientes con c\u00e1ncer y se confirm\u00f3 la utilidad de 10 de ellas como biomarcadores diagn\u00f3sticos de la enfermedad. Mediante estad\u00edstica multivariante se gener\u00f3 un modelo con elevada sensibilidad (95%), especificidad (81%) y precisi\u00f3n diagn\u00f3stica (92%), basado en la determinaci\u00f3n de cinco de estas prote\u00ednas. en resumen, este trabajo ha permitido identificar nuevos biomarcadores proteicos de c\u00e1ncer de pulm\u00f3n en el lab con elevada capacidad diagn\u00f3stica. Su cuantificaci\u00f3n podr\u00eda contribuir a mejorar el diagn\u00f3stico temprano de la enfermedad y, en consecuencia, incrementar la supervivencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>B\u00fasqueda, identificaci\u00f3n y validaci\u00f3n de biomarcadores moleculares de c\u00e1ncer de pulm\u00f3n mediante t\u00e9cnicas prote\u00f3micas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 B\u00fasqueda, identificaci\u00f3n y validaci\u00f3n de biomarcadores moleculares de c\u00e1ncer de pulm\u00f3n mediante t\u00e9cnicas prote\u00f3micas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Uribarri Ormaza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/06\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Bego\u00f1a Ruiz Arguello<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alicia Alonso izquierdo <\/li>\n<li>carmen P\u00e9rez Garc\u00eda (vocal)<\/li>\n<li>rub\u00e9n Pio os\u00e9s (vocal)<\/li>\n<li>Rafael Zalacain Jorge (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Uribarri Ormaza La falta de m\u00e9todos que permitan una detecci\u00f3n temprana del c\u00e1ncer de pulm\u00f3n ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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