{"id":109682,"date":"2018-03-11T10:35:16","date_gmt":"2018-03-11T10:35:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/molecular-determinants-of-trpv4-channel-regulation\/"},"modified":"2018-03-11T10:35:16","modified_gmt":"2018-03-11T10:35:16","slug":"molecular-determinants-of-trpv4-channel-regulation","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia\/molecular-determinants-of-trpv4-channel-regulation\/","title":{"rendered":"Molecular determinants of trpv4 channel regulation"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Garcia-elias Heras <\/strong><\/h2>\n<p>El canal trpv4 es un canal cati\u00f3nico no selectivo de expresi\u00f3n generalizada y funciones diversas. Aunque inicialmente se describi\u00f3 como un osmoregulador sist\u00e9mico, hoy en d\u00eda sabemos que tambi\u00e9n se puede activar por temperatura o por aumentos en el volumen celular. Debido a la diversidad de est\u00edmulos, el canal presenta diferentes v\u00edas de activaci\u00f3n, la mayor\u00eda de las cuales son desconocidas. Esta tesis pretende estudiar en detalle los mecanismos moleculares que regulan la actividad del canal. Aportamos evidencias del sitio de uni\u00f3n del receptor de inositol trisfosfato as\u00ed como su modulaci\u00f3n de la actividad del trpv4. Tambi\u00e9n discutimos el papel de la cola n-terminal en la osmotransducci\u00f3n y presentamos una mutaci\u00f3n, generadora de un canal con una respuesta an\u00f3mala a est\u00edmulos hipot\u00f3nicos, que est\u00e1 asociada a una condici\u00f3n fisiopatol\u00f3gica como la hiponatremia. Tambi\u00e9n destacamos la importancia de la cola n-terminal y de la uni\u00f3n a la prote\u00edna reguladora pacsin3 en la conformaci\u00f3n general del canal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Molecular determinants of trpv4 channel regulation<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Molecular determinants of trpv4 channel regulation <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Garcia-elias Heras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel \u00e1ngel Valverde De Castro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Lopez lopez <\/li>\n<li>joris Vriens (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Garcia-elias Heras El canal trpv4 es un canal cati\u00f3nico no selectivo de expresi\u00f3n generalizada y funciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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