{"id":109724,"date":"2011-01-07T00:00:00","date_gmt":"2011-01-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activacion-constitutiva-de-la-va%c2%ada-de-senalizacion-hedgehog-en-linfomas-linfoblasticos-t-por-la-sobre-expresion-del-gen-smoothened\/"},"modified":"2011-01-07T00:00:00","modified_gmt":"2011-01-07T00:00:00","slug":"activacion-constitutiva-de-la-va%c2%ada-de-senalizacion-hedgehog-en-linfomas-linfoblasticos-t-por-la-sobre-expresion-del-gen-smoothened","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/activacion-constitutiva-de-la-va%c2%ada-de-senalizacion-hedgehog-en-linfomas-linfoblasticos-t-por-la-sobre-expresion-del-gen-smoothened\/","title":{"rendered":"\u00abactivaci\u00f3n constitutiva de la v\u00edade se\u00f1alizaci\u00f3n hedgehog en linfomas linfobl\u00e1sticos t por la sobre-expresi\u00f3n del gen smoothened\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Gonzalez Gugel <\/strong><\/h2>\n<p>La v\u00eda gli\/hedgehog ha recibido especial atenci\u00f3n, no s\u00f3lo por su implicaci\u00f3n como regulador del desarrollo embrionario sino tambi\u00e9n por la contribuci\u00f3n de sus alteraciones en el desarrollo y evoluci\u00f3n de diferentes tipos de c\u00e1nceres. La activaci\u00f3n de la v\u00eda se ha relacionado con la generaci\u00f3n de diversos tipos de c\u00e1nceres s\u00f3lidos e incluso de c\u00e9lulas b, pero no con el desarrollo de linfomas t. La v\u00eda gli\/hedgehog se ha visto principalmente alterada debido a mutaciones inactivantes en ptch, y s\u00f3lo en un 10% de los carcinomas de c\u00e9lulas basales se han descrito mutaciones activantes de smo (el \u00fanico elemento no redundante de la v\u00eda). En esta tesis demostramos que el gen ort\u00f3logo de rat\u00f3n, smo, se encuentra sobre-expresado en linfomas linfobl\u00e1sticos t inducidos mediante radiaci\u00f3n gamma, y que este hecho supone la activaci\u00f3n de la v\u00eda gli\/hh. Tambi\u00e9n demostramos la sobre-expresi\u00f3n del gen smo en muestra humanas de linfomas linfobl\u00e1sticos t y en l\u00edneas tumorales humanas derivadas de linfomas linfobl\u00e1sticos t. Los tratamientos con un antagonista de smo, la ciclopamina, tienen efectos claros en la disminuci\u00f3n de la viabilidad y proliferaci\u00f3n celular, alteran el ciclo celular e incluso aumentan los niveles de muerte celular por apoptosis. La sobreexpresi\u00f3n de este gen, produce los efectos contrarios. La sobre-expresi\u00f3n de smo en los linfomas linfobl\u00e1sticos t se puede explicar mediante la bajada de expresi\u00f3n de micro-arns espec\u00edficos, que son diferentes en las muestras humanas y de rat\u00f3n. nuestros datos evidencian la importancia de la sobreexpresi\u00f3n de smoothened en el desarrollo y\/o mantenimiento de este tipo de linfomas, y sugieren que el control de la via gli\/hh pudiera ser una nueva estrategia de atenci\u00f3n en el tratamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abactivaci\u00f3n constitutiva de la v\u00edade se\u00f1alizaci\u00f3n hedgehog en linfomas linfobl\u00e1sticos t por la sobre-expresi\u00f3n del gen smoothened\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abactivaci\u00f3n constitutiva de la v\u00edade se\u00f1alizaci\u00f3n hedgehog en linfomas linfobl\u00e1sticos t por la sobre-expresi\u00f3n del gen smoothened\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Gonzalez Gugel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  C. Villa Morales<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jos\u00e9 Gonz\u00e1lez aguilera <\/li>\n<li>Jos\u00e9 Manuel Martin villa (vocal)<\/li>\n<li>beatriz Martinez delgado (vocal)<\/li>\n<li>felix Manzarbeitia arambarri (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Gonzalez Gugel La v\u00eda gli\/hedgehog ha recibido especial atenci\u00f3n, no s\u00f3lo por su implicaci\u00f3n como regulador [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,962],"tags":[131275,219352,102086,23123,14863,124871],"class_list":["post-109724","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-genetica","tag-beatriz-Martinez-delgado","tag-elena-gonzalez-gugel","tag-felix-manzarbeitia-arambarri","tag-jose-manuel-martin-villa","tag-juan-jose-gonzalez-aguilera","tag-maria-c-villa-morales"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/109724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=109724"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/109724\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=109724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=109724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=109724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}