{"id":109791,"date":"2011-01-07T00:00:00","date_gmt":"2011-01-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilizacion-de-la-granulacion-por-fusion-en-la-obtencion-de-comprimidos-matriciales-de-liberacion-modificada\/"},"modified":"2011-01-07T00:00:00","modified_gmt":"2011-01-07T00:00:00","slug":"utilizacion-de-la-granulacion-por-fusion-en-la-obtencion-de-comprimidos-matriciales-de-liberacion-modificada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/utilizacion-de-la-granulacion-por-fusion-en-la-obtencion-de-comprimidos-matriciales-de-liberacion-modificada\/","title":{"rendered":"Utilizaci\u00f3n de la granulaci\u00f3n por fusi\u00f3n en la obtenci\u00f3n de comprimidos matriciales de liberaci\u00f3n modificada"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Ochoa Diaz De Monasterioguren <\/strong><\/h2>\n<p>Este trabajo recoge la aplicaci\u00f3n de un proceso de granulaci\u00f3n por fus\u00ed\u00f3n en un solo paso para el desarrollo de comprimidos de liberaci\u00f3n modificada de teofilina y lovastatina. En primer lugar, se realiz\u00f3 la caracterizaci\u00f3n de las formulaciones desarrolladas y se estudi\u00f3 la influencia de los excipientes en el perfil de disoluci\u00f3n y en el mecanismo de liberaci\u00f3n del f\u00e1rmaco a partir de los comprimidos matriciales elaborados. Adem\u00e1s, se estudi\u00f3 el comportamiento in vivo y la farmacocin\u00e9tica de ambas formulaciones en perros beagle, evaluando el efecto de los alimentos en la absorci\u00f3n del f\u00e1rmaco en el caso de la formulaci\u00f3n de lovastatina. los resultados obtenidos demostraron que la elecci\u00f3n del aglutinante permite modificar el perfil de liberaci\u00f3n in vitro del f\u00e1rmaco. La combinaci\u00f3n de una celulosa de menor viscosidad (hpmc k4m) con aglutinantes hidr\u00f3filos (peg 6000 y gelucire\u00c2\u00ae50\/13) dio lugar a mayores porcentajes de f\u00e1rmaco disuelto. Los comprimidos matriciales desarrollados presentaban un perfil de liberaci\u00f3n del f\u00e1rmaco independiente del ph del medio de disoluci\u00f3n, siendo la cin\u00e9tica de liberaci\u00f3n no lineal para la teofilina y de orden zero para la lovastatina. Los comprimidos de teofilina proporcionaron niveles sostenidos del f\u00e1rmaco en plasma y una excelente correlaci\u00f3n in vitro-in vivo de nivel a. En el caso de la formulaci\u00f3n de lovastatina, se obtuvieron niveles plasm\u00e1ticos sostenidos del f\u00e1rmaco y de su metabolito, lovastatina \u00e1cida, tanto en ayunas como en presencia de alimentos. Se detectaron diferencias estad\u00edsticamente significativas en algunos par\u00e1metros farmacocin\u00e9ticos de lovastatina \u00e1cida que parecen indicar que los alimentos con alto contenido en grasa aumentan la absorci\u00f3n de lovastatina a partir de la nueva formulaci\u00f3n desarrollada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilizaci\u00f3n de la granulaci\u00f3n por fusi\u00f3n en la obtenci\u00f3n de comprimidos matriciales de liberaci\u00f3n modificada<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilizaci\u00f3n de la granulaci\u00f3n por fusi\u00f3n en la obtenci\u00f3n de comprimidos matriciales de liberaci\u00f3n modificada <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Ochoa Diaz De Monasterioguren <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Mart\u00ednez pacheco <\/li>\n<li>ibon Gutierro aduriz (vocal)<\/li>\n<li>Mar\u00eda  rosa Jimenez castellanos ballesteros (vocal)<\/li>\n<li>rosa Mar\u00eda Hernandez martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Ochoa Diaz De Monasterioguren Este trabajo recoge la aplicaci\u00f3n de un proceso de granulaci\u00f3n por fus\u00ed\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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