{"id":109887,"date":"2011-06-07T00:00:00","date_gmt":"2011-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monoterapia-inmunosupresora-con-micofenolato-mofetilo-en-enfermos-trasplantados-de-ha%c2%adgado-con-nefropata%c2%ada-cronica-por-anticalcineura%c2%adnicos\/"},"modified":"2011-06-07T00:00:00","modified_gmt":"2011-06-07T00:00:00","slug":"monoterapia-inmunosupresora-con-micofenolato-mofetilo-en-enfermos-trasplantados-de-ha%c2%adgado-con-nefropata%c2%ada-cronica-por-anticalcineura%c2%adnicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/monoterapia-inmunosupresora-con-micofenolato-mofetilo-en-enfermos-trasplantados-de-ha%c2%adgado-con-nefropata%c2%ada-cronica-por-anticalcineura%c2%adnicos\/","title":{"rendered":"Monoterapia inmunosupresora con micofenolato mofetilo en enfermos trasplantados de h\u00edgado con nefropat\u00edacr\u00f3nica por anticalcineur\u00ednicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Ortega Domene <\/strong><\/h2>\n<p>Introducci\u00f3n: la nefrotoxicidad asociada al tratamiento cr\u00f3nico con anticalceneur\u00ednicos (inc) supone la categor\u00eda de disfunci\u00f3n renal (dr) m\u00e1s frecuente tras el trasplante hep\u00e1tico (th). Una alternativa es la introducci\u00f3n de monoterapia con micofenol ato mofetilo (mmf). objetivo: evaluar la evoluci\u00f3n de la funci\u00f3n renal de los receptores de th con nefrotoxicidad asociada al uso cr\u00f3nico de inc, sustituyendo estos por mmf en monoterapia, con la intenci\u00f3n de mejorar la funci\u00f3n renal. material y m\u00e9to dos: la muestra se obtuvo a partir de la poblaci\u00f3n de trasplantados hep\u00e1ticos en el hospital universitario doce de octubre de Madrid entre 07\/07\/1986 y 09\/06\/2005, escogiendo aquellos que en alg\u00fan momento de su seguimiento pasaron a protocolo de mono terapia con mmf y cumpl\u00edan los criterios de inclusi\u00f3n. El seguimiento se cerr\u00f3 en abril de 2009.  se trata de un estudio observacional, anal\u00edtico, tipo cohorte retrospectiva y prospectiva.  resultados: la substituci\u00f3n de los inc por monoterapia con m mf se realiz\u00f3 en 91 pacientes (66 varones), con una edad media de 52 a\u00f1os (rango: 23-69 a\u00f1os), por presentar nefrotoxicidad asociada al tratamiento cr\u00f3nico con inc aislada (n=59), o asociada a otros efectos secundarios (n=32). la funci\u00f3n renal se est udi\u00f3 registrando las cifras de creatinina y el aclaramiento de creatinina (aco) seg\u00fan la f\u00f3rmula de cockroft-gault. la mediana de seguimiento en monoterapia con mmf fue de 36 meses, con un rango intercuart\u00edlico de 24-60 meses. se observ\u00f3 un descenso significativo de las cifras de creatinina y un aumento significativo del aco, sin incrementarse la tasa de rechazos o deteriorarse la funci\u00f3n hep\u00e1tica. conclusiones: la monoterapia con mmf mejora la funci\u00f3n renal en trasplantados hep\u00e1ticos con nefrot oxicidad asociada al uso cr\u00f3nico de inc, sin aumentar la tasa de rechazo y mejorando otros efectos asociados al uso cr\u00f3nico de inc (hipertensi\u00f3n arterial, diabetes, hipercolesterolemia, hipertrigliceridemia y neurotoxicidad).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monoterapia inmunosupresora con micofenolato mofetilo en enfermos trasplantados de h\u00edgado con nefropat\u00edacr\u00f3nica por anticalcineur\u00ednicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monoterapia inmunosupresora con micofenolato mofetilo en enfermos trasplantados de h\u00edgado con nefropat\u00edacr\u00f3nica por anticalcineur\u00ednicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Ortega Domene <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Carlos Jim\u00e9nez Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  jose Torres Garc\u00eda <\/li>\n<li>Jos\u00e9 Antonio Rodr\u00edguez montes (vocal)<\/li>\n<li>Jos\u00e9 Manuel Figueroa andollo (vocal)<\/li>\n<li>Javier Nu\u00f1o vazquez garza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Ortega Domene Introducci\u00f3n: la nefrotoxicidad asociada al tratamiento cr\u00f3nico con anticalceneur\u00ednicos (inc) supone la categor\u00eda de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,986],"tags":[15009,31821,3775,206516,196294,219603],"class_list":["post-109887","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-complutense-de-madrid","tag-antonio-jose-torres-garcia","tag-javier-nuno-vazquez-garza","tag-jose-antonio-rodriguez-montes","tag-jose-manuel-figueroa-andollo","tag-luis-carlos-jimenez-romero","tag-patricia-ortega-domene"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/109887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=109887"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/109887\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=109887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=109887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=109887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}