{"id":109941,"date":"2011-07-07T00:00:00","date_gmt":"2011-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/involvement-of-fak-focal-adhesion-kinase-in-head-and-neck-squamous-cell-carcinoma-progression\/"},"modified":"2011-07-07T00:00:00","modified_gmt":"2011-07-07T00:00:00","slug":"involvement-of-fak-focal-adhesion-kinase-in-head-and-neck-squamous-cell-carcinoma-progression","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/involvement-of-fak-focal-adhesion-kinase-in-head-and-neck-squamous-cell-carcinoma-progression\/","title":{"rendered":"Involvement of fak (focal adhesion kinase) in head and neck squamous cell carcinoma progression."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Garz\u00f3n Arango <\/strong><\/h2>\n<p>La prote\u00edna quinasa presente en los contactos focales, focal adhesion kinase (fak), se encuentra sobreexpresada en carcinomas epidermoides de cabeza y cuello (cecc) y sus met\u00e1stasis linf\u00e1ticas y su expresi\u00f3n es mayor en tumores que metastatizan versus los que no metastatizan lo que sugiere que fak puede tener un papel activo en invasi\u00f3n y migraci\u00f3n celular en cecc. De hecho, estudios in vitro han puesto de manifiesto que fak regula la migraci\u00f3n e invasi\u00f3n celular en diferentes tipos de c\u00e1ncer entre los que se incluyen los cecc. En el presente trabajo de investigaci\u00f3n, se ha estudiado el mecanismo bioqu\u00edmico por el que fak regula la invasi\u00f3n y migraci\u00f3n celular en cecc. Se ha identificado a la prote\u00edna rho-gtpasa, rac1, como mol\u00e9cula clave mediadora de la regulaci\u00f3n de la migraci\u00f3n e invasi\u00f3n celular ejercida por fak en cecc. La inhibici\u00f3n de la actividad\/expresi\u00f3n de fak en c\u00e9lulas de cecc se acompa\u00f1a de un aumento en la actividad de rac1. Adem\u00e1s, la inhibici\u00f3n conjunta de rac1 y fak rescata el fenotipo de menor capacidad invasiva celular producida por la inhibici\u00f3n de fak en solitario. Nuestros resultados sugieren que fak podr\u00eda ser considerada una gran diana terap\u00e9utica para el control de la progresi\u00f3n de los cecc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Involvement of fak (focal adhesion kinase) in head and neck squamous cell carcinoma progression.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Involvement of fak (focal adhesion kinase) in head and neck squamous cell carcinoma progression. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Garz\u00f3n Arango <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Suarez Nieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: xos\u00e9 ant\u00f3n Su\u00e1rez puente <\/li>\n<li>karl H\u00ed\u00b6rmann (vocal)<\/li>\n<li>giuseppe Spriano (vocal)<\/li>\n<li>Jos\u00e9 ignacio Piruat  palomo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Garz\u00f3n Arango La prote\u00edna quinasa presente en los contactos focales, focal adhesion kinase (fak), se encuentra [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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