{"id":109988,"date":"2011-08-07T00:00:00","date_gmt":"2011-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-ciclooxigenasa-en-un-modelo-de-dano-pulmonar-inducido-por-ventilacion-mecanica\/"},"modified":"2011-08-07T00:00:00","modified_gmt":"2011-08-07T00:00:00","slug":"papel-de-la-ciclooxigenasa-en-un-modelo-de-dano-pulmonar-inducido-por-ventilacion-mecanica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-ciclooxigenasa-en-un-modelo-de-dano-pulmonar-inducido-por-ventilacion-mecanica\/","title":{"rendered":"Papel de la ciclooxigenasa en un modelo de da\u00f1o pulmonar inducido por ventilaci\u00f3n mec\u00e1nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angela Algaba Calderon <\/strong><\/h2>\n<p>Papel de la ciclooxigenasa en un modelo de da\u00f1o pulmonar inducido por ventilaci\u00f3n mec\u00e1nica doctorando: \u00e1ngela algaba calder\u00f3n. directores: jos\u00e9 \u00e1ngel lorente balanza. Rafael enr\u00edquez de salamanca lorente.  introducci\u00f3n  la ventilaci\u00f3n mec\u00e1nica es el tratamiento de soporte de los pacientes con s\u00edndrome de distr\u00e9s respiratorio agudo, sin embargo puede producir o agravar la insuficiencia respiratoria, entidad que se denomina lesi\u00f3n pulmonar aguda inducida por ventilaci\u00f3n mec\u00e1nica (vili). Dentro de esta patolog\u00eda, es desconocido el papel que juega la enzima ciclooxigenasa (cox) y los productos derivados del \u00e1cido araquid\u00f3nico.   hip\u00f3tesis  la ciclooxigenasa y sus metabolitos tienen un papel fundamental en el desarrollo del da\u00f1o pulmonar y cardi ovascular secundario al uso de ventilaci\u00f3n mec\u00e1nica con par\u00e1metros lesivos (vili). La inhibici\u00f3n de la cox conduce a efectos beneficiosos sobre la funci\u00f3n pulmonar y cardiovascular en el vili  material y m\u00e9todos los procedimientos siguen los principi os de laboratorio animal (eu 609\/86 cee, rd 1201\/2005 boe -10\/10). Ratas sprague-dawley fueron anestesiadas, traqueostomizadas y ventiladas desde t=0 durante 120 minutos con dos estrategias: protectora y nociva. Se aleatorizaron para tres tratamiento s distintos: valerilsalicilato (inhibidor espec\u00edfico de cox-1), nimesulide (inhibidor espec\u00edfico de cox-2), indometacina (inhibidor inespec\u00edfico de cox). Se midieron par\u00e1metros hemodin\u00e1micos y de mec\u00e1nica respiratoria. En t=120 el animal fue sacrific ado y se realiz\u00f3: gasometr\u00eda arterial, determinaci\u00f3n de bioqu\u00edmica b\u00e1sica, mip-2 e il-6 en suero, lavado broncoalveolar (bal), extracci\u00f3n de tejido pulmonar para an\u00e1lisis histol\u00f3gico y expresi\u00f3n gen\u00e9tica de cox, mip-2 e il-6.  resultados el tratamien to con inhibidores de la cox, espec\u00edficos e inespec\u00edficos, atenu\u00f3 la disfunci\u00f3n pulmonar (menor afectaci\u00f3n del intercambio gaseoso y de la mec\u00e1nica respiratoria) y cardiovascular (menor deterioro de la presi\u00f3n arterial) asociada al vili.   conclusion es se acepta la hip\u00f3tesis principal del estudio: la ciclooxigenasa y sus metabolitos tienen un papel fundamental en el desarrollo del da\u00f1o pulmonar y  cardiovascular secundario al uso de ventilaci\u00f3n mec\u00e1nica con par\u00e1metros lesivos. La inhibici\u00f3n de l a cox conduce a efectos beneficiosos sobre la funci\u00f3n pulmonar y cardiovascular en el vili<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la ciclooxigenasa en un modelo de da\u00f1o pulmonar inducido por ventilaci\u00f3n mec\u00e1nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la ciclooxigenasa en un modelo de da\u00f1o pulmonar inducido por ventilaci\u00f3n mec\u00e1nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angela Algaba Calderon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 \u00e1ngel Lorente Balanza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Alvarez sala walther <\/li>\n<li>federico natalio Gordo vidal (vocal)<\/li>\n<li>leticia Martinez caro (vocal)<\/li>\n<li>Andr\u00e9s Esteban de la torre (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angela Algaba Calderon Papel de la ciclooxigenasa en un modelo de da\u00f1o pulmonar inducido por ventilaci\u00f3n mec\u00e1nica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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