{"id":11001,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/sintesis-de-acidos-2-aril-propionicos-homoquirales-mediante-esterificacion-enantioselectiva-catalizada-por-lipasas-inmovilizadas\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"sintesis-de-acidos-2-aril-propionicos-homoquirales-mediante-esterificacion-enantioselectiva-catalizada-por-lipasas-inmovilizadas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-de-acidos-2-aril-propionicos-homoquirales-mediante-esterificacion-enantioselectiva-catalizada-por-lipasas-inmovilizadas\/","title":{"rendered":"Sintesis de acidos 2-aril propionicos homoquirales mediante esterificacion enantioselectiva catalizada por lipasas inmovilizadas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Arroyo S\u00e1nchez <\/strong><\/h2>\n<p>Muchos farmacos sinteticos se emplean como mezclas racemicas, aunque el efecto terapeutico solo resida en uno de los enantiomeros. Un ejemplo lo encontramos en los antiinflamatorios no esteroidicos de la familia de los acidos 2-aril propionicos, donde solo el isomero s(+) es activo. La industria farmaceutica se ha planteado sustituir la sintesis asimetrica de los isomeros s(+), que es cara y poco eficaz, por la resolucion enzimatica de las mezclas racemicas mediante el empleo de lipasas.  pero estas lipasas se deben inmovilizar para disponer de biocatalizadores estables y activos durante mucho tiempo, y que se puedan reutilizar, de tal forma que el proceso biotecnologico sea rentable. Para ello, se ha procedido a la obtencion de derivados inmovilizados de lipasa comercial de c. Rugosa y de lipasa b de c. Antarctica activos y estables, por union covalente a soportes con buenas propiedades mecanicas. Estos derivados se han empleado en la esterificacion de los acidos 2-aril propionicos en el seno de un medio organico, y se han analizado los factores que influyen en la reaccion: el tipo de disolvente, tipo de alcohol, la estructura del acido y las variables tecnicas del proceso (temperatura, agitacion, relacion molar acido\/alcohol, cantidad de biocatalizador y agua en el medio). A continuacion, se ha estudiado la estereoselectividad de las esterificaciones catalizadas por las dos lipasas, siendo la lipasa b de c.  antarctica la mas indicada para la resolucion de los antiinflamatorios no esteroidicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de acidos 2-aril propionicos homoquirales mediante esterificacion enantioselectiva catalizada por lipasas inmovilizadas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de acidos 2-aril propionicos homoquirales mediante esterificacion enantioselectiva catalizada por lipasas inmovilizadas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Arroyo S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Vicente Sinisterra Gago<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pablo Sanz Pedrero <\/li>\n<li>Antonio Espinosa \u00fabeda (vocal)<\/li>\n<li>Mar\u00eda Del Carmen Avenda\u00f1o L\u00f3pez (vocal)<\/li>\n<li>\u00e1ngel Alberola Figueroa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Arroyo S\u00e1nchez Muchos farmacos sinteticos se emplean como mezclas racemicas, aunque el efecto terapeutico solo resida [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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