{"id":110033,"date":"2011-08-07T00:00:00","date_gmt":"2011-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/functional-and-structural-study-of-a-novel-transmembrane-protein-and-its-role-in-autophagy\/"},"modified":"2011-08-07T00:00:00","modified_gmt":"2011-08-07T00:00:00","slug":"functional-and-structural-study-of-a-novel-transmembrane-protein-and-its-role-in-autophagy","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/functional-and-structural-study-of-a-novel-transmembrane-protein-and-its-role-in-autophagy\/","title":{"rendered":"Functional and structural study of a novel transmembrane protein and its role in autophagy"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Kathrin Pallauf <\/strong><\/h2>\n<p>Macroautophagy refers to bulk degradation of cytoplasmic contents by sequestration in a vesicle called autophagosome which fuses with the lysosome. After degradation the molecules obtained can be reused. Macroautophagy works as a starvation response und thus is regulated by the ser\/thr kinase tor (target of rapamycin). The formation of the autophagosome is mediated by the autophagy related proteins, the atgs. Atg5 and atg7 are part of the ubiquitin-like systems that promote elongation of the autophagosome membrane by lipidating another atg atg8\/lc3.  excessive macroautophagy can lead to cell death which made it possible to identify an autophagy inducer in our laboratory by screening a cdna library for cell death inducers. As the protein encoded for by the identified cdna has a structure similar to many transmembrane receptors, we named this protein autophagy inducing receptor (air).  in this thesis a functional and structural study of this protein is carried out. It is found to be a transmembrane protein type i that transiently localises to the cell membrane but predominantly localises to the endosomal-lysosomal compartments. The over-expressed protein induces autophagy in various human cell lines. The functional domain for this property was found to be the intracellular region, as the intracellular domain is necessary and sufficient to induce autophagy. Within this region the autophagy inducing properties could be ascribed to a 19 amino acid region. The pathway induced by this protein depends on the core autophagy related proteins atg5 and atg7.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Functional and structural study of a novel transmembrane protein and its role in autophagy<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Functional and structural study of a novel transmembrane protein and its role in autophagy <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Kathrin Pallauf <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felipe Pimentel Mui\u00f1os<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: faustino Mollinedo Garc\u00eda <\/li>\n<li>ines Mar\u00eda Anton gutierrez (vocal)<\/li>\n<li>ignacio Moreno de albor\u00e1n (vocal)<\/li>\n<li>Mar\u00eda   Jos\u00e9 Caloca roldan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Kathrin Pallauf Macroautophagy refers to bulk degradation of cytoplasmic contents by sequestration in a vesicle called autophagosome [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,9386],"tags":[5661,143096,195119,140458,219823,4472],"class_list":["post-110033","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-salamanca","tag-faustino-mollinedo-garcia","tag-felipe-pimentel-muinos","tag-ignacio-moreno-de-alboran","tag-ines-maria-anton-gutierrez","tag-kathrin-pallauf","tag-maria-jose-caloca-roldan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/110033","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=110033"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/110033\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=110033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=110033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=110033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}