{"id":110145,"date":"2011-12-07T00:00:00","date_gmt":"2011-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/spatial-control-of-inner-ear-neurogenesis-by-retinoic-acid-tbx1-and-her-genes\/"},"modified":"2011-12-07T00:00:00","modified_gmt":"2011-12-07T00:00:00","slug":"spatial-control-of-inner-ear-neurogenesis-by-retinoic-acid-tbx1-and-her-genes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pompeu-fabra\/spatial-control-of-inner-ear-neurogenesis-by-retinoic-acid-tbx1-and-her-genes\/","title":{"rendered":"Spatial control of inner ear neurogenesis by retinoic acid, tbx1 and her genes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marija Radosevic <\/strong><\/h2>\n<p>Sensory neurons are key mediators of the transduction of external stimuli from the ear to the brain essential for the sense of balance and hearing. Understanding when, where and how the sensory nervous system is assembled during development can provide insights on deafness and balance disorders. Here, i show in zebrafish that her9 transcription factor is a key element in the regulation of otic neurogenesis. Loss of her9 function leads to the ectopic expression of neurogenic genes neurod and neurod4. Moreover, i show that her9 acts downstream of tbx1, and both genes are activated by retinoic acid signaling emanating from the paraxial mesoderm and negatively regulated by hedgehog signaling. Altogether, the data demonstrates a role of retinoic acid in axial patterning and the establishment of a neurogenic domain through tbx1 and her9. At later stages, retinoic acid has an additional role by regulating neuronal differentiation in the statoacoustic ganglion.  los neurones sensoriales del o\u00eddo interno son mediadores claves en la transducci\u00f3n de los estimulos externos desde el o\u00eddo interno hac\u00eda el cerebro. Entender donde, cuando y como se organiza el sistema nerviosa sensorial durante el desarrollo del embri\u00f3n, puede ayudar en el estudio de los malformaciones neurosensoriales.En la presente tes\u00eds, muestro que en pez cebra, el factor de transcripci\u00f3n her9 es un elemento esencial en el control de la neurogenesis otica y que her9 se encuentra bajo el control directo del factor tbx1. Adem\u00e1s, ambos factores est\u00e1n regulados de manera positiva por la v\u00eda de la se\u00f1alizaci\u00f3n del acido retinoico y negativamente por la v\u00eda de hedgehog. En resumen, la tesis demuestra un papel del acido retinoico en la regionalizaci\u00f3n axial del primordio otico, en el eje anteroposterior, y el establecimiento de un dominio neurogenico a traves de funcion inhibitora de los factores tbx1 y her9. En estadios mas avanzados, acido retinoico regula la diferenciaci\u00f3n neuronal en el ganglio estato-ac\u00fastico<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Spatial control of inner ear neurogenesis by retinoic acid, tbx1 and her genes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Spatial control of inner ear neurogenesis by retinoic acid, tbx1 and her genes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marija Radosevic <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Berta Alsina I Espa\u00f1ol<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: paola Bovolenta nicolao <\/li>\n<li>tanya Whitfield (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marija Radosevic Sensory neurons are key mediators of the transduction of external stimuli from the ear to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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