{"id":110256,"date":"2018-03-11T10:36:09","date_gmt":"2018-03-11T10:36:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-teorico-de-la-reaccion-catalizada-por-la-enzima-glutamato-racemasa-activacion-del-sustrato-y-mecanismo\/"},"modified":"2018-03-11T10:36:09","modified_gmt":"2018-03-11T10:36:09","slug":"estudio-teorico-de-la-reaccion-catalizada-por-la-enzima-glutamato-racemasa-activacion-del-sustrato-y-mecanismo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-fisica\/estudio-teorico-de-la-reaccion-catalizada-por-la-enzima-glutamato-racemasa-activacion-del-sustrato-y-mecanismo\/","title":{"rendered":"Estudio te\u00f3rico de la reacci\u00f3n catalizada por la enzima glutamato racemasa: activaci\u00f3n del sustrato y mecanismo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduard Puig Alvarez <\/strong><\/h2>\n<p>La reacci\u00f3n catalizada por la enzima glutamato racemasa consiste en la interconversi\u00f3n de los enanti\u00f3meros del glutamato. El mecanismo de reacci\u00f3n requiere de la rotura del enlace calfa-halfa del amino\u00e1cido por una ciste\u00edna y su posterior formaci\u00f3n por la cara enantiom\u00e9ricamente opuesta por otra ciste\u00edna. En esta tesis se ha estudiado el mecanismo de reacci\u00f3n de esta enzima, que lleva a cabo la desprotonaci\u00f3n de un prot\u00f3n tan poco \u00e1cido con una base tan d\u00e9bil y, adem\u00e1s, lo consigue sin la necesidad de un cofactor. el estudio de las curvas de titraci\u00f3n y los c\u00e1lculos de pka muestran que la forma ionizada de la ciste\u00edna se encuentra poco favorecida y que el amino\u00e1cido, en el centro activo, se encuentra mayoritariamente en su forma neutra. El ion tiolato, encargado de desprotonar el calfa, es poco estable y su existencia debe de ser por lo tanto m\u00ednima. La reacci\u00f3n es posible mediante un mecanismo de asistencia al tiol, que consiste en la colaboraci\u00f3n de residuos adyacentes que se encargan de desprotonar el tiol aceptor, antes de que \u00e9ste desprotone el calfa del sustrato, y que se encargan de reprotonar el tiol dador, una vez reprotonado el calfa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio te\u00f3rico de la reacci\u00f3n catalizada por la enzima glutamato racemasa: activaci\u00f3n del sustrato y mecanismo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio te\u00f3rico de la reacci\u00f3n catalizada por la enzima glutamato racemasa: activaci\u00f3n del sustrato y mecanismo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduard Puig Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mireia Garc\u00eda Viloca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Moliner ib\u00e1\u00f1ez <\/li>\n<li>victor (secretario) Guallar tasies (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduard Puig Alvarez La reacci\u00f3n catalizada por la enzima glutamato racemasa consiste en la interconversi\u00f3n de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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