{"id":110355,"date":"2018-03-11T10:36:19","date_gmt":"2018-03-11T10:36:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/generacion-y-aplicacion-de-anticuerpos-recombinantes-in-vivo\/"},"modified":"2018-03-11T10:36:19","modified_gmt":"2018-03-11T10:36:19","slug":"generacion-y-aplicacion-de-anticuerpos-recombinantes-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/generacion-y-aplicacion-de-anticuerpos-recombinantes-in-vivo\/","title":{"rendered":"Generaci\u00f3n y aplicaci\u00f3n de anticuerpos recombinantes in vivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David S\u00e1nchez Mart\u00edn <\/strong><\/h2>\n<p>La tecnolog\u00eda de presentaci\u00f3n de p\u00e9ptidos y prote\u00ednas en la superficie de fagos filamentosos (phage display) es actualmente uno de los sistemas m\u00e1s utilizados para la obtenci\u00f3n de anticuerpos, generalmente a partir de ant\u00edgeno purificado o suspensiones homog\u00e9neas de c\u00e9lulas. En este trabajo, esta tecnolog\u00eda se ha adaptado para la generaci\u00f3n de anticuerpos frente a ant\u00edgenos en su contexto nativo en modelos animales in vivo. como fuente de diversidad se han empleado repertorios humanos en formato de fragmento variable de cadena \u00fanica o en formato monodominio. se han identificado y modificado algunos par\u00e1metros decisivos en la evoluci\u00f3n de la selecci\u00f3n, lo que ha permitido la obtenci\u00f3n de anticuerpos recombinantes capaces de localizar espec\u00edficamente dep\u00f3sitos tumorales en distintos formatos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Generaci\u00f3n y aplicaci\u00f3n de anticuerpos recombinantes in vivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Generaci\u00f3n y aplicaci\u00f3n de anticuerpos recombinantes in vivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David S\u00e1nchez Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis \u00e1lvarez Vallina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: africa Gonzalez fernandez <\/li>\n<li>alicia Garc\u00eda arroyo (vocal)<\/li>\n<li>ricardo S\u00e1nchez prieto (vocal)<\/li>\n<li>Jos\u00e9 ignacio Casal alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David S\u00e1nchez Mart\u00edn La tecnolog\u00eda de presentaci\u00f3n de p\u00e9ptidos y prote\u00ednas en la superficie de fagos filamentosos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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