{"id":110369,"date":"2018-03-11T10:36:19","date_gmt":"2018-03-11T10:36:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-membrana-en-el-mecanismo-de-neutralizacion-del-vih-por-el-anticuerpo-anti-mper-2f5\/"},"modified":"2018-03-11T10:36:19","modified_gmt":"2018-03-11T10:36:19","slug":"implicacion-de-la-membrana-en-el-mecanismo-de-neutralizacion-del-vih-por-el-anticuerpo-anti-mper-2f5","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/proteinas\/implicacion-de-la-membrana-en-el-mecanismo-de-neutralizacion-del-vih-por-el-anticuerpo-anti-mper-2f5\/","title":{"rendered":"Implicaci\u00f3n de la membrana en el mecanismo de neutralizaci\u00f3n del vih por el anticuerpo anti-mper 2f5"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruben Maeso Gallego <\/strong><\/h2>\n<p>Este trabajo de tesis se ha centrado en el estudio de la implicaci\u00f3n del contexto lip\u00eddico en el mecanismo de neutralizaci\u00f3n del anticuerpo anti-mper 2f5 y en la b\u00fasqueda de las claves necesarias para alcanzar una respuesta inmune neutralizante similar a la observada con el mab2f5.   el anticuerpo 2f5 raramente se produce a lo largo de la infecci\u00f3n natural por vih-1, pero posee, sin embargo, la capacidad de neutralizar un amplio espectro de cepas del virus. Su ep\u00edtopo se localiza en el n-terminal de la regi\u00f3n externa pr\u00f3xima a la membrana, mper, de la subunidad gp41 de la glicoprote\u00edna de envuelta, env, del vih-1; y tras su uni\u00f3n, el anticuerpo es capaz de bloquear el proceso de fusi\u00f3n entre la membrana viral y  celular en la que participa esta regi\u00f3n. Sin embargo, se desconoce el mecanismo de acci\u00f3n del mab2f5 a nivel molecular y por tanto, los aspectos y claves que convierten a este anticuerpo en neutralizante frente a aquellos, que aun siendo capaces de unirse con esta regi\u00f3n, no lo son.  en esta tesis intentamos dilucidar si el mab2f5 es capaz de interaccionar con l\u00edpidos y si lo hace a trav\u00e9s del lazo cdr h3, que en este tipo de anticuerpos es significativamente largo e hidrof\u00f3bico. Posteriormente, se intent\u00f3 analizar el efecto de los l\u00edpidos como componente adicional de una vacuna frente al ep\u00edtopo 2f5.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de la membrana en el mecanismo de neutralizaci\u00f3n del vih por el anticuerpo anti-mper 2f5<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de la membrana en el mecanismo de neutralizaci\u00f3n del vih por el anticuerpo anti-mper 2f5 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruben Maeso Gallego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Nieva Escad\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Rodriguez arrondo <\/li>\n<li>maier Lorizate nogales (vocal)<\/li>\n<li>Jes\u00fas Perez gil (vocal)<\/li>\n<li>enrique Perez paya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruben Maeso Gallego Este trabajo de tesis se ha centrado en el estudio de la implicaci\u00f3n del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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