{"id":110408,"date":"2018-03-11T10:36:24","date_gmt":"2018-03-11T10:36:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-validacion-de-un-metodo-de-diagnostico-no-invasivo-de-cancer-de-prostata\/"},"modified":"2018-03-11T10:36:24","modified_gmt":"2018-03-11T10:36:24","slug":"desarrollo-y-validacion-de-un-metodo-de-diagnostico-no-invasivo-de-cancer-de-prostata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/desarrollo-y-validacion-de-un-metodo-de-diagnostico-no-invasivo-de-cancer-de-prostata\/","title":{"rendered":"Desarrollo y validaci\u00f3n de un m\u00e9todo de diagn\u00f3stico no invasivo de c\u00e1ncer de pr\u00f3stata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Saioa Dominguez Hormaetxe <\/strong><\/h2>\n<p>El c\u00e1ncer de pr\u00f3stata es el tipo de tumor m\u00e1s frecuente en problaci\u00f3n masculina, y la tercera causa de muerte por c\u00e1ncer en varones. El procedimiento actual para su diagn\u00f3stico implica la determinaci\u00f3n del marcador psa en sangre a modo de cribado poblacional en varones a partir de 50 a\u00f1os, y en caso de ser positivo, una biopsia prost\u00e1tica. El principal problema de este sistema es la baja especificidad (25%) del psa, y la limitada sensibilidad de la biopsia (70%). As\u00ed, un elevado porcentaje de hombres sanos o con patolog\u00edas benignas de la pr\u00f3stata son sometidos a biopsias prost\u00e1ticas de manera reiterada a lo largo de su vida, por presentar valores elevados de psa y biopsias negativas. Es por ello, que resulta de vital importancia el desarrollo de sistemas de diagn\u00f3stico no invasivos que complementen el cribado poblacional por psa, para evitar la intervenci\u00f3n quir\u00fargica a individuos sanos. el objetivo de esta tesis doctoral es la b\u00fasqueda de nuevos biomarcadores proteicos de c\u00e1ncer de pr\u00f3stata en orina y el desarrollo de un m\u00e9todo de diagn\u00f3stico, apto para la rutina cl\u00ednica, basado en la detecci\u00f3n de los mismos mediante inmunoensayos. tras el an\u00e1lisis prote\u00f3mico comparativo por 2de-page de 163 orinas donadas por pacientes con c\u00e1ncer de pr\u00f3stata e individuos sanos con psa elevado, fueron identificadas 23 prote\u00ednas cuya presencia urinaria result\u00f3 diferencial en ambos grupos. Se desarrollaron inmunoensayos para 8 de ellas basados en la tecnolog\u00eda de microesferas xmap\u00c2\u00ae de luminex, y la utilidad diagn\u00f3stica de los mismos fue verificada analizando una poblaci\u00f3n de 268 muestras de orina. Klk3 se valid\u00f3 como marcador diagn\u00f3stico para c\u00e1ncer de pr\u00f3stata, y su aplicaci\u00f3n en cl\u00ednica, combinada con la edad de los pacientes y el volumen prost\u00e1tico, podr\u00eda mejorar el diagn\u00f3stico actual de la enfermedad, evitando el 40% de las biopsias innecesarias.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y validaci\u00f3n de un m\u00e9todo de diagn\u00f3stico no invasivo de c\u00e1ncer de pr\u00f3stata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y validaci\u00f3n de un m\u00e9todo de diagn\u00f3stico no invasivo de c\u00e1ncer de pr\u00f3stata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Saioa Dominguez Hormaetxe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Itsaso Hormaeche Berciano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Rodriguez arrondo <\/li>\n<li>Jos\u00e9 Villanueva cardus (vocal)<\/li>\n<li>Antonio L\u00f3pez beltr\u00e1n (vocal)<\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Saioa Dominguez Hormaetxe El c\u00e1ncer de pr\u00f3stata es el tipo de tumor m\u00e1s frecuente en problaci\u00f3n masculina, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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