{"id":110545,"date":"2018-03-11T10:36:35","date_gmt":"2018-03-11T10:36:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-diferenciacion-de-las-vesa%c2%adculas-opticas-en-condiciones-normales-y-en-modelos-de-ciclopia\/"},"modified":"2018-03-11T10:36:35","modified_gmt":"2018-03-11T10:36:35","slug":"desarrollo-y-diferenciacion-de-las-vesa%c2%adculas-opticas-en-condiciones-normales-y-en-modelos-de-ciclopia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/desarrollo-animal\/desarrollo-y-diferenciacion-de-las-vesa%c2%adculas-opticas-en-condiciones-normales-y-en-modelos-de-ciclopia\/","title":{"rendered":"Desarrollo y diferenciaci\u00f3n de las ves\u00edculas \u00f3pticas en condiciones normales y en modelos de ciclopia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Adri\u00e1n Santos Ledo <\/strong><\/h2>\n<p>La exposici\u00f3n a etanol retrasa la migraci\u00f3n de las c\u00e9lulas celulares durante la gastrulaci\u00f3n, lo que conduce a problemas en la especificaci\u00f3n de la regi\u00f3n anterior del embri\u00f3n. Adem\u00e1s, en la placa neural anterior, el etanol impide la evaginaci\u00f3n de las ves\u00edculas \u00f3pticas, resultando en ciclopia, y retrasa la diferenciaci\u00f3n del sistema visual. Sin embargo, los mecanismos por los cuales el etanol afecta la morfog\u00e9nesis y diferenciaci\u00f3n del sistema visual no se conocen. el objetivo de este trabajo es analizar los posibles efectos de la exposici\u00f3n a etanol sobre el desarrollo del sistema visual en tres momentos del desarrollo del sistema visual. La exposici\u00f3n a etanol retrasa la migraci\u00f3n de los progenitores de la placa precordal disminuyendo la adhesi\u00f3n entre ellos y aumentando la expresi\u00f3n de rnd1. Hemos observado que, durante la divisi\u00f3n del campo visual, la exposici\u00f3n a etanol altera los patrones de expresi\u00f3n de algunos genes que intervienen en este proceso (rx3, rx1, pax6a y six3a) de manera dosis dependiente. Adem\u00e1s, despu\u00e9s de la exposici\u00f3n a etanol las c\u00e9lulas del campo visual no adquieren morfolog\u00edas alargadas ni se polarizan correctamente. A partir de los 2 d\u00edas, hemos visto que los efectos del etanol en la diferenciaci\u00f3n del sistema visual dependen del tipo celular. A los 5 d\u00edas, algunos marcadores celulares recuperan niveles normales de expresi\u00f3n, aunque la diferenciaci\u00f3n general comenz\u00f3 con retraso en los embriones cicl\u00f3peos. la teratogenia et\u00edlica podr\u00eda relacionarse no s\u00f3lo con modificaciones en la expresi\u00f3n g\u00e9nica sino tambi\u00e9n con alteraciones en la morfolog\u00eda celular. La plasticidad neural que presenta el sistema visual del pez cebra hace que sea un buen modelo in vivo para ensayos qu\u00edmicos que reduzcan el da\u00f1o neurol\u00f3gico producido por sustancias teratog\u00e9nicas. financiado con becas del micinn (bfu2009-11179), junta de castilla y le\u00f3n (grupo de excelencia gr-183) y consejer\u00eda de sanidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y diferenciaci\u00f3n de las ves\u00edculas \u00f3pticas en condiciones normales y en modelos de ciclopia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y diferenciaci\u00f3n de las ves\u00edculas \u00f3pticas en condiciones normales y en modelos de ciclopia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Adri\u00e1n Santos Ledo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Arevalo Arevalo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: raquel emilia Rodr\u00edguez rodr\u00edguez <\/li>\n<li>florencia (secretario) Cavodeassi madarro (vocal)<\/li>\n<li>diego Clemente l\u00f3pez (vocal)<\/li>\n<li>Carlos Crespo ruperez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Adri\u00e1n Santos Ledo La exposici\u00f3n a etanol retrasa la migraci\u00f3n de las c\u00e9lulas celulares durante la gastrulaci\u00f3n, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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