{"id":110567,"date":"2018-03-11T10:36:41","date_gmt":"2018-03-11T10:36:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-en-el-desarrollo-y-la-longevidad-del-gen-gale-1-en-caenorhabditis-elegans-un-modelo-animal-de-galactosemia-tipo-iii\/"},"modified":"2018-03-11T10:36:41","modified_gmt":"2018-03-11T10:36:41","slug":"implicaciones-en-el-desarrollo-y-la-longevidad-del-gen-gale-1-en-caenorhabditis-elegans-un-modelo-animal-de-galactosemia-tipo-iii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/implicaciones-en-el-desarrollo-y-la-longevidad-del-gen-gale-1-en-caenorhabditis-elegans-un-modelo-animal-de-galactosemia-tipo-iii\/","title":{"rendered":"Implicaciones en el desarrollo y la longevidad del gen gale-1 en caenorhabditis elegans: un modelo animal de galactosemia tipo iii."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Mar\u00eda Brokate Llanos <\/strong><\/h2>\n<p>El objetivo inicial de este trabajo ha sido caracterizar el gen gale-1 y entender su relaci\u00f3n con el proceso de longevidad a trav\u00e9s de mutantes de p\u00e9rdida o reducci\u00f3n de funci\u00f3n en caenorhabditis elegans. En la caracterizaci\u00f3n del mutante de reducci\u00f3n de funci\u00f3n, gale-1(pv18),  encontramos una gran variedad de fenotipos: la termotolerancia a 30\u00c2\u00bac, la letalidad embrionaria a 25\u00c2\u00bac, la longevidad en el estadio l4 a 25 y 20\u00c2\u00bac, puesta de huevos y progenie tard\u00eda a 20\u00c2\u00bac, retraso en el crecimiento, vulva protuberante y malformaci\u00f3n de g\u00f3nadas a cualquier temperatura y condici\u00f3n de crecimiento, sin embargo, el mutante de p\u00e9rdida de funci\u00f3n, gale-1(tm3267),  result\u00f3 ser letal. El hecho de que mutantes de reducci\u00f3n de funci\u00f3n del gen hom\u00f3logo a gale-1 en humanos (gale) genere galactosemia tipo iii, una enfermedad poco estudiada, ha hecho que el objetivo se haya ampliado para entender esta enfermedad en un modelo biol\u00f3gico animal. En resumen, podemos decir que la falta total de funci\u00f3n es letal como se ha propuesto en humanos y que una reducci\u00f3n de funci\u00f3n debido a la mutaci\u00f3n pv18 que es mas similar a los alelos encontrados en humanos, es viable aunque presenta numerosos problemas, sensibilidad a galactosa y problemas de desarrollo, atribuibles a fallos en glicosilaci\u00f3n, los cuales concuerdan con fenotipos descritos en humanos.  adem\u00e1s, la longevidad de gale-1(pv18) no se debe a una supervivencia a la infecci\u00f3n, ni una reducci\u00f3n del proceso de n-glicosilaci\u00f3n y si puede estar relacionada con una restricci\u00f3n dietar\u00eda. Tambi\u00e9n se han encontrado interacciones con rutas relacionadas con la longevidad, la ruta de la unfolded protein response y la ruta de la insulina, que puede ser los factores intr\u00ednsecos de gale-1 para conferir un incremento de longevidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones en el desarrollo y la longevidad del gen gale-1 en caenorhabditis elegans: un modelo animal de galactosemia tipo iii.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones en el desarrollo y la longevidad del gen gale-1 en caenorhabditis elegans: un modelo animal de galactosemia tipo iii. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Mar\u00eda Brokate Llanos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pablo de olavide<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel J. Mu\u00f1oz Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ruiz rubio <\/li>\n<li>belen Perez gonzalez (vocal)<\/li>\n<li>Juan Cabello pardos (vocal)<\/li>\n<li>noem\u00ed Cabrera poch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Mar\u00eda Brokate Llanos El objetivo inicial de este trabajo ha sido caracterizar el gen gale-1 y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[962,37365,11414,37286],"tags":[220666,15232,172875,208870,61716,220667],"class_list":["post-110567","post","type-post","status-publish","format-standard","hentry","category-genetica","category-genetica-del-desarrollo","category-metabolismo-humano","category-pablo-de-olavide","tag-ana-maria-brokate-llanos","tag-belen-perez-gonzalez","tag-juan-cabello-pardos","tag-manuel-j-munoz-ruiz","tag-manuel-ruiz-rubio","tag-noemi-cabrera-poch"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/110567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=110567"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/110567\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=110567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=110567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=110567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}