{"id":11065,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/valoracion-inmunologica-y-factores-pronosticos-en-pacientes-con-melanoma-maligno-tratados-con-inmunoterapia\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"valoracion-inmunologica-y-factores-pronosticos-en-pacientes-con-melanoma-maligno-tratados-con-inmunoterapia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-inmunologica-y-factores-pronosticos-en-pacientes-con-melanoma-maligno-tratados-con-inmunoterapia\/","title":{"rendered":"Valoracion inmunologica y factores pronosticos en pacientes con melanoma maligno tratados con inmunoterapia."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Caloto Gonzalez M. Teresa <\/strong><\/h2>\n<p>Se recogen los resultados obtenidos en una poblacion de 194 pacientes diagnosticados de melanoma maligno y remitidos a la seccion de inmuno-oncolog\u00eda del h.G.U.  gregorio mara\u00f1on de Madrid. A todos ellos se les administro inmunoterapia adoptiva (celulas pak y t-lak) e inmunoterapia activa inespecifica (bcg y, a los pacientes con estadio iv, ifn-alfa) y se monitorizaron trece variables inmunologicas. Se observa un aumento de la supervivencia en comparacion con otras series descritas.  es efectivo, sobre todo, como tratamiento adyuvante en pacientes con estadios ii, iii y iva los que se les ha extirpado aparentemente toda la masa tumoral.  practicamente no se observa toxicidad asociada. Los factores pronosticos de la supervivencia se determinan segun el modelo de regresion de riesgos proporcionales de cox. Un porcentaje de linfocitos t antes del tratamiento menor de 60% esta asociado con un mejor pronostico (riesgo 0,30). La supervivencia es menor cuando no se observa tras el tratamiento un aumento de los linfocitos t colaboradores, un aumento en la capacidad proliferativa frente a fitohemaglutinina o una disminucion de los niveles sericos de interferon-gamma. De las caracteristicas clinico-demograficas, tienen valor pronostico el sexo, estadio y tipo histologico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoracion inmunologica y factores pronosticos en pacientes con melanoma maligno tratados con inmunoterapia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoracion inmunologica y factores pronosticos en pacientes con melanoma maligno tratados con inmunoterapia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Caloto Gonzalez M. Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidro Valladares Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Javier Leceta Martinez <\/li>\n<li>Jos\u00e9 Ramon Regueiro  Gonzalez Barros (vocal)<\/li>\n<li>Jes\u00fas Millan Nu\u00f1ez Cortes (vocal)<\/li>\n<li>G. Alvarez Naves (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Caloto Gonzalez M. Teresa Se recogen los resultados obtenidos en una poblacion de 194 pacientes diagnosticados de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,1737,1027,156],"tags":[36377,36379,36378,22955,1552,4671],"class_list":["post-11065","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-inmunologia","category-oncologia","category-patologia","tag-caloto-gonzalez-m-teresa","tag-g-alvarez-naves","tag-isidro-valladares-sanchez","tag-javier-leceta-Martinez","tag-jesus-millan-nunez-cortes","tag-jose-ramon-regueiro-gonzalez-barros"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11065","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=11065"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11065\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=11065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=11065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=11065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}