{"id":110748,"date":"2011-05-09T00:00:00","date_gmt":"2011-05-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-genetica-en-la-respuesta-analgesica-a-la-buprenorfina-transdermica-en-ciruga%c2%ada-toracica\/"},"modified":"2011-05-09T00:00:00","modified_gmt":"2011-05-09T00:00:00","slug":"influencia-genetica-en-la-respuesta-analgesica-a-la-buprenorfina-transdermica-en-ciruga%c2%ada-toracica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/anestesiologia-quirurgica\/influencia-genetica-en-la-respuesta-analgesica-a-la-buprenorfina-transdermica-en-ciruga%c2%ada-toracica\/","title":{"rendered":"Influencia gen\u00e9tica en la respuesta analg\u00e9sica a la buprenorfina transd\u00e9rmica en cirugia tor\u00e1cica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Alfonso Sastre Rinc\u00f3n <\/strong><\/h2>\n<p>Objetivos del estudio  la existencia de diferentes variantes gen\u00e9ticas ocasionadas por la presencia de polimorfismos dan lugar a la presencia de distintos fenotipos en cuanto a la eficacia de los opioides y a la aparici\u00f3n de efectos adversos. El objetivo de nuestro estudio ha sido valorar si la presencia de  polimorfismos que afectan al metabolismo de la buprenorfina o a los receptores opioides puede influir en la analgesia mediada por la misma o en la aparici\u00f3n de efectos adversos. pacientes y m\u00e9todo se estudiaron 87 pacientes sometidos a cirug\u00eda tor\u00e1cica y que recibieron analgesia con buprenorfina tts. Se estudi\u00f3 la presencia de los siguientes polimorfismos: cyp3a4*1b, 1934g>a del gen cyp2d6, 802c>t del gen ugt2b7, 118a>g del gen oprm1, 1443a>t del gen oprm1, 843a>g del gen oprk1. Se valor\u00f3 la analgesia mediante una eva de 10 puntos a las 0, 1, 2, 6, 12, 24, 36, 48, 60, 72, 96, 120 y 144 horas y se recogi\u00f3 la aparici\u00f3n de efectos adversos. La asociaci\u00f3n entre estas variables se estudi\u00f3 mediante el test estad\u00edstico apropiado en cada caso.  resultados se observa que los pacientes homocig\u00f3ticos salvajes para el gen ugt2b7 presentan puntuaciones de la eva inferiores en casi todas las determinaciones del dolor en reposo y con la tos; tambi\u00e9n se observa en ellos una menor incidencia de dolor severo (p>0,05). Los pacientes homocig\u00f3ticos salvajes para el gen oprk1 presentan cierta tendencia a tener una mejor respuesta analg\u00e9sica al tratamiento con buprenorfina transd\u00e9rmica. No se observan diferencias estad\u00edsticamente significativas en la respuesta analg\u00e9sica para los otros polimorfismos; tampoco se ha observado que la aparici\u00f3n de efectos adversos se asocie con la presencia de un determinado polimorfismo. conclusiones la presencia de los polimorfismos 802c>t del gen ugt2b7 y 843a>g del gen oprk1 modifica la respuesta analg\u00e9sica a la buprenorfina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia gen\u00e9tica en la respuesta analg\u00e9sica a la buprenorfina transd\u00e9rmica en cirugia tor\u00e1cica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia gen\u00e9tica en la respuesta analg\u00e9sica a la buprenorfina transd\u00e9rmica en cirugia tor\u00e1cica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Alfonso Sastre Rinc\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/09\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Clemente Muriel Villoria<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Palanca san Francisco <\/li>\n<li>eduardo Tamayo gomez (vocal)<\/li>\n<li>marcelo Fernando Jimenez lopez (vocal)<\/li>\n<li>isabel S\u00e1nchez magro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Alfonso Sastre Rinc\u00f3n Objetivos del estudio la existencia de diferentes variantes gen\u00e9ticas ocasionadas por la presencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1569,10954,2820,9386],"tags":[9871,122164,208119,220954,8550,218154],"class_list":["post-110748","post","type-post","status-publish","format-standard","hentry","category-anestesiologia-quirurgica","category-cirugia-pulmonar","category-genetica-humana","category-salamanca","tag-clemente-muriel-villoria","tag-eduardo-tamayo-gomez","tag-isabel-sanchez-magro","tag-jose-alfonso-sastre-rincon","tag-jose-maria-palanca-san-francisco","tag-marcelo-fernando-jimenez-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/110748","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=110748"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/110748\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=110748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=110748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=110748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}