{"id":110771,"date":"2011-06-09T00:00:00","date_gmt":"2011-06-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-reseccion-hepatica-sobre-el-comportamiento-de-las-celulas-tumorales-residuales-y-utilidad-del-atra-para-controlar-dicho-efecto-en-un-modelo-experimental\/"},"modified":"2011-06-09T00:00:00","modified_gmt":"2011-06-09T00:00:00","slug":"efecto-de-la-reseccion-hepatica-sobre-el-comportamiento-de-las-celulas-tumorales-residuales-y-utilidad-del-atra-para-controlar-dicho-efecto-en-un-modelo-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/efecto-de-la-reseccion-hepatica-sobre-el-comportamiento-de-las-celulas-tumorales-residuales-y-utilidad-del-atra-para-controlar-dicho-efecto-en-un-modelo-experimental\/","title":{"rendered":"Efecto de la resecci\u00f3n hep\u00e1tica sobre el comportamiento de las c\u00e9lulas tumorales residuales y utilidad del atra para controlar dicho efecto en un modelo experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> I\u00f1aki Diaz Sanz <\/strong><\/h2>\n<p>Las neoplasias colorrectales representan la tercera causa de patolog\u00eda neopl\u00e1sica y son responsables del 10% de las muertes por c\u00e1ncer. Es por ello por lo que urge un mayor estudio de los mecanismos que intervienen en dicho proceso.   en este trabajo se demuestra el efecto potenciador de la cirug\u00eda de resecci\u00f3n sobre el desarrollo metast\u00e1sico, as\u00ed como la capacidad del \u00e1cido retinoico (atra) y del 5-fluorouracilo (5-fu) para frenar dicho efecto, tanto in vitro como in vivo.   en los experimentos in vitro, se analiza el efecto de diversas mol\u00e9culas sobre el ritmo proliferativo de cultivos de la l\u00ednea celular cc-531, lo que se estima mediante curvas de crecimiento obtenidas mediante nucleocounter, recuento al hemocit\u00f3metro, espectrofotometr\u00eda de mtt y xcelligence. Para las experiencias in vivo se han inducido met\u00e1stasis hep\u00e1ticas mediante inyecci\u00f3n intraespl\u00e9cnica de c\u00e9lulas cc-531 en ratas wag\/rijcrl. En ese modelo se ha estudiado el efecto de la hepatectom\u00eda parcial (l\u00f3bulo lateral izquierdo) sobre el desarrollo tumoral, as\u00ed como la modificaci\u00f3n del mismo producida por el tratamiento con atra y\/o 5-fu.  a la luz de los resultados obtenidos, se puede afirmar que: 1.\tEl suero obtenido de ratas sometidas a hepatectom\u00eda parcial y los factores de crecimiento ensayados (vegf, hgf, fgfb, pdgf, egf) estimulan la proliferaci\u00f3n celular in vitro. Del mismo modo, la hepatectom\u00eda parcial incrementa el desarrollo de met\u00e1stasis hep\u00e1ticas.   2.\tEl atra anula el efecto proliferativo de los fc estudiados, in vitro.  3.\tEl atra retrasa el desarrollo de met\u00e1stasis hep\u00e1ticas en ratas; si bien, esto no conlleva un incremento del periodo de supervivencia. 4.\tEl atra refuerza el efecto antiproliferativo del 5-fu sobre los cultivos de cc-531, sin que dicho efecto haya sido posible demostrarlo in vivo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la resecci\u00f3n hep\u00e1tica sobre el comportamiento de las c\u00e9lulas tumorales residuales y utilidad del atra para controlar dicho efecto en un modelo experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la resecci\u00f3n hep\u00e1tica sobre el comportamiento de las c\u00e9lulas tumorales residuales y utilidad del atra para controlar dicho efecto en un modelo experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 I\u00f1aki Diaz Sanz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/09\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Teodoro Palomares Casado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Mendez martin <\/li>\n<li>Juan  Francisco del Ca\u00f1izo l\u00f3pez (vocal)<\/li>\n<li>Luis Garcia  sancho martin (vocal)<\/li>\n<li>Javier Garcia criado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de I\u00f1aki Diaz Sanz Las neoplasias colorrectales representan la tercera causa de patolog\u00eda neopl\u00e1sica y son responsables del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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