{"id":110866,"date":"2018-03-11T10:37:09","date_gmt":"2018-03-11T10:37:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/a-link-between-loss-of-developmentally-controlled-gene-silencing-and-tumor-growth\/"},"modified":"2018-03-11T10:37:09","modified_gmt":"2018-03-11T10:37:09","slug":"a-link-between-loss-of-developmentally-controlled-gene-silencing-and-tumor-growth","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/a-link-between-loss-of-developmentally-controlled-gene-silencing-and-tumor-growth\/","title":{"rendered":"A link between loss of developmentally controlled gene silencing and tumor growth"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Janic <\/strong><\/h2>\n<p>El primer capitulo incluye el articulo en que hemos descrito como crecimiento maligno de los tumores causados por mutaciones en drosophila l(3)mbt esta causado por una transformaci\u00f3n de la l\u00ednea som\u00e1tica hacia  la l\u00ednea germinal. Esta transformaci\u00f3n se debe a la expresi\u00f3n ect\u00f3pica de genes de la l\u00ednea germinal que confieren caracter\u00edsticas, como fitness (valor adaptativo), longevidad y stemness (pluripotencia) . La inactivacion de cualquiera de estos genes, como piwi, nanos, vasa  o aubergine  suprime  el crecimiento maligno de los tumores causados por  mutaciones  en l(3)mbt . Los ortologos  de algunos de estos genes tambi\u00e9n se encuentran  expresados ectopicamente en canceres humanos. Nuestro trabajo demuestra que las caracter\u00edsticas de l\u00ednea germinal  son necesarias para el crecimiento tumoral,  en   este  modelo de drosophila y que la  inactivacion de genes espec\u00edficos de l\u00ednea germinal podr\u00eda tener un efecto inhibitorio en el crecimiento tumoral en otras especies [1].   el segundo capitulo incluye el articulo en que hemos descrito como las c\u00e9lulas de ojo de drosophila que son mutantes en el gen ph, que codifica por polyhomeiotic, una de  las policomb group (pcg) prote\u00edna, pierden su capacidad de diferenciaci\u00f3n, as\u00ed como la polaridad. Esta c\u00e9lulas proliferan de manera descontrolada e invaden los tejidos vecinos. En combinaci\u00f3n  con la  sobreexpresion del oncog\u00e9n ras  tambi\u00e9n inducen la formaci\u00f3n de met\u00e1stasis. Las prote\u00ednas pcg se unen a diferentes genes, de la v\u00eda de notch, controlando su transcripci\u00f3n y as\u00ed afectando  la se\u00f1alizaci\u00f3n de esta prote\u00edna. Esta sobreproliferacion puede ser rescatada  tanto con  la sobreeexprsesion del  mutante dominante negativo de notch  as\u00ed como con  la inactivacion  mediante rna interferente de este gen. De manera reciproca, la sobreexpression de ph produce un  fenotipo de ojo peque\u00f1o  que  puede ser rescatado por la activaci\u00f3n de notch. Estos resultado  demuestran que ph  es un supresor tumoral, que controla la proliferaci\u00f3n celular, a trav\u00e9s de la inativacion de la se\u00f1alizaci\u00f3n de la v\u00eda de notch [2].    bibliograf\u00eda 1. Janic a, mendizabal l, llamazares s, rossell d, gonzalez c: ectopic expression of germline genes drives malignant brain tumor growth in drosophila. Science 2010, 330:1824-1827. 2. Martinez am, schuettengruber b, sakr s, janic a, gonzalez c, cavalli g: polyhomeotic has a tumor suppressor activity mediated by repression of notch signaling. Nat genet 2009, 41:1076-1082.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>A link between loss of developmentally controlled gene silencing and tumor growth<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 A link between loss of developmentally controlled gene silencing and tumor growth <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Janic <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/09\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cayetano Gonz\u00e1lez Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: acaimo Gonz\u00e1lez reyes <\/li>\n<li>Andrea Brand (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Janic El primer capitulo incluye el articulo en que hemos descrito como crecimiento maligno de los 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