{"id":110921,"date":"2018-03-11T10:37:09","date_gmt":"2018-03-11T10:37:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-protector-de-la-melatonina-y-del-tratamiento-topico-con-lidocaina-y-prilocaina-emla-en-un-modelo-de-isquemia-repercusion-en-el-colgajo-cutaneo-microvascularizado-en-ratas\/"},"modified":"2018-03-11T10:37:09","modified_gmt":"2018-03-11T10:37:09","slug":"efecto-protector-de-la-melatonina-y-del-tratamiento-topico-con-lidocaina-y-prilocaina-emla-en-un-modelo-de-isquemia-repercusion-en-el-colgajo-cutaneo-microvascularizado-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-de-trasplantes\/efecto-protector-de-la-melatonina-y-del-tratamiento-topico-con-lidocaina-y-prilocaina-emla-en-un-modelo-de-isquemia-repercusion-en-el-colgajo-cutaneo-microvascularizado-en-ratas\/","title":{"rendered":"Efecto protector de la melatonina y del tratamiento topico con lidocaina y prilocaina (emla) en un modelo de isquemia-repercusion en el colgajo cutaneo microvascularizado en ratas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cesar Casado Sanchez <\/strong><\/h2>\n<p>El s\u00edndrome de isquemia reperfusi\u00f3n (sir) es un factor desencadenante del fracaso de los colgajos cut\u00e1neos microvascularizados. Entre las opciones encaminadas a controlar el estr\u00e9s oxidativo (eo) como mecanismo patog\u00e9nico en el sir, la melatonina (como antioxidante) y la mezcla de los anest\u00e9sicos lidoca\u00edna y priloca\u00edna (mediante su efecto vasodilatador) podr\u00edan ser una alternativa terap\u00e9utica. Para analizar el papel de ambos f\u00e1rmacos se dise\u00f1\u00f3 un estudio experimental en el que se compararon los efectos de ambas terapias de forma individual y combinada, evaluadas en dos modelos de isquemia-reperfusi\u00f3n (ir) basados en per\u00edodos de isquemia diferentes (de 6 y de 12 horas) en el colgajo epig\u00e1strico en la rata wistar. Para su evaluaci\u00f3n se midieron par\u00e1metros bioqu\u00edmicos de eo (glutati\u00f3n total, relaci\u00f3n glutati\u00f3n reducido \/ glutati\u00f3n oxidado, super\u00f3xido dismutasa y productos de lipoperoxidaci\u00f3n o sustancias que reaccionan con el \u00e1cido tiobarbit\u00farico) y par\u00e1metros histol\u00f3gicos (edema dermoepid\u00e9rmico, infiltrado inflamatorio, apoptosis y neovascularizaci\u00f3n). Los modelos de ir basados en 12 horas de isquemia expresaron con mayor intensidad los cambios bioqu\u00edmicos e histol\u00f3gicos. La administraci\u00f3n de melatonina mejor\u00f3 los marcadores bioqu\u00edmicos asociando un descenso del infiltrado inflamatorio y de los marcadores de apoptosis. La aplicaci\u00f3n de la mezcla de anest\u00e9sicos mejor\u00f3 los par\u00e1metros bioqu\u00edmicos y descendi\u00f3 el infiltrado inflamatorio y la apoptosis (aunque esto \u00faltimo menos que el indol), asociando adem\u00e1s un incremento en la neovascularizaci\u00f3n de los colgajos. El empleo de ambos de forma combinada ofreci\u00f3 resultados similares a los obtenidos con su administraci\u00f3n aislada, y potenci\u00f3 el desarrollo de la neovascularizaci\u00f3n en los colgajos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto protector de la melatonina y del tratamiento topico con lidocaina y prilocaina (emla) en un modelo de isquemia-repercusion en el colgajo cutaneo microvascularizado en ratas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto protector de la melatonina y del tratamiento topico con lidocaina y prilocaina (emla) en un modelo de isquemia-repercusion en el colgajo cutaneo microvascularizado en ratas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cesar Casado Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Fernando Rioja Torrejon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Lopez miranda <\/li>\n<li>abelardo Garc\u00eda de lorenzo (vocal)<\/li>\n<li>Francisco Jos\u00e9 Martelo villar (vocal)<\/li>\n<li>Carlos Vaquero puerta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cesar Casado Sanchez El s\u00edndrome de isquemia reperfusi\u00f3n (sir) es un factor desencadenante del fracaso de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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