{"id":11096,"date":"2001-04-06T00:00:00","date_gmt":"2001-04-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmuniprofilaxis-en-la-enfermedad-de-chagas-desarrollo-de-una-vacuna-genetica\/"},"modified":"2001-04-06T00:00:00","modified_gmt":"2001-04-06T00:00:00","slug":"inmuniprofilaxis-en-la-enfermedad-de-chagas-desarrollo-de-una-vacuna-genetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/inmuniprofilaxis-en-la-enfermedad-de-chagas-desarrollo-de-una-vacuna-genetica\/","title":{"rendered":"Inmuniprofilaxis en la enfermedad de chagas. desarrollo de una vacuna gen\u00e9tica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Planelles Carazo <\/strong><\/h2>\n<p>Trypanosoma cruzi es un protozoo par\u00e1sito, agente causal de la enfermedad de chagas. En el desarrollo de la tesis se establecen los modelos murinos de susceptibilidad y resistencia a la infecci\u00f3n. Cuando los ratones balb\/c se infectan con t. Cruzi,experimentan elevadas parasitemias que conducen a la muerte de lso animales. Sin embargo, los ratones de la cepa c57bl\/6, tras la infecci\u00f3n, controlan r\u00e1pidamente el pico de parasitemia con una tasa de supervivencia del 100%. El an\u00e1lisis del perfil de citoquinas para las c\u00e9lulas t cd3+ del bazo muestra que los ratones resistentes c57bl\/6 presentan una mayor producic\u00f3n d eifn-y e il-2 y menor de il-10 que la observa en los ratones bakb\/c sensibles. Las poblaciones de macr\u00f3fagos y c\u00e9lulas dentr\u00edticas de bazo se encuentran incrementadas en ambas cepas tras la infecci\u00f3n por t. Cruzi. En esta c\u00e9lulas las mol\u00e9culas de coestimulaci\u00f3n cd40 y cd86 est\u00e1n inhibidas enla cepa susceptible y no en la resitente. el an\u00e1lisis del peritoneo revela que los ratones balb\/c y c57bl\/6 presentan tras la infecci\u00f3n, un aumento de la poblaci\u00f3n de c\u00e9lulas t cd3+ con un diferente perfil de citoquinas, caracterizado por uan mayor producci\u00f3n de il-4 y menor de tnf-a en ratones susceptibles, y un incremento de ifn-y en los resistentes. Adem\u00e1s, solo en los ratones resistentes aumentan los macr\u00f3fagos del peritoneo, mostrando una expresi\u00f3n preferente de citoquinas de tipo th1.  el an\u00e1lisis sobre la antigenicidad de la prote\u00edna kmp11 de t. Cruzi pone de manifiesto que los sueros de pacientes chag\u00e1sicos presentan altos t\u00edtulos de anticuerpos frente a la prote\u00edna kmp11 de t. Cruzi, los cuales, a diferencia de lo que ocurre con sueros de personas con leishmaniasis, reconocen de manera sensible y espec\u00edfica dos determinantes antig\u00e9nicos lineales. Por otra parte,la prote\u00edna recombiante kmp11 de t. Cruzi muestra ser en modelos experimental es murinos un potente inmun\u00f3geno celular. En el contexto de inmuni<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmuniprofilaxis en la enfermedad de chagas. desarrollo de una vacuna gen\u00e9tica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmuniprofilaxis en la enfermedad de chagas. desarrollo de una vacuna gen\u00e9tica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Planelles Carazo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Carlos L\u00f3pez L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Alonso bedate <\/li>\n<li>gerardo Alvarez de cienfuegos lopez (vocal)<\/li>\n<li>Manuel Segovia hern\u00e1ndez (vocal)<\/li>\n<li>basilio Valladares hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Planelles Carazo Trypanosoma cruzi es un protozoo par\u00e1sito, agente causal de la enfermedad de chagas. En [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1738,36483,160,115,35,1737,17,2714],"tags":[35395,4386,3688,36484,3722,3373],"class_list":["post-11096","post","type-post","status-publish","format-standard","hentry","category-antigenos","category-biologia-molecular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-inmunologia","category-quimica","category-vacunas","tag-basilio-valladares-hernandez","tag-carlos-alonso-bedate","tag-gerardo-alvarez-de-cienfuegos-lopez","tag-lourdes-planelles-carazo","tag-manuel-carlos-lopez-lopez","tag-manuel-segovia-hernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=11096"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11096\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=11096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=11096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=11096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}