{"id":11101,"date":"2001-04-06T00:00:00","date_gmt":"2001-04-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelo-animal-para-el-estudio-de-la-recirculacion-corporal-del-metotrexato-y-su-interrupcion-con-colestipol\/"},"modified":"2001-04-06T00:00:00","modified_gmt":"2001-04-06T00:00:00","slug":"modelo-animal-para-el-estudio-de-la-recirculacion-corporal-del-metotrexato-y-su-interrupcion-con-colestipol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modelo-animal-para-el-estudio-de-la-recirculacion-corporal-del-metotrexato-y-su-interrupcion-con-colestipol\/","title":{"rendered":"Modelo animal para el estudio de la recirculaci\u00f3n corporal del metotrexato y su interrupci\u00f3n con colestipol."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandra G\u00f3mez Palomo <\/strong><\/h2>\n<p>Se ha dise\u00f1ado un modelo animal para el estudio de la farmacocin\u00e9tica del metotrexato en distintas situaciones de eliminaci\u00f3n as\u00ed como el estudio de los mecanismos y  procesos de recirculaci\u00f3n corporal del metrotrexato y su interrupci\u00f3n con colestipol. La administraci\u00f3n por v\u00eda oral de colestipol tiene como mecanismo de acci\u00f3n principal el secuestro en el lumen intestinal de la fracci\u00f3n de medicamento presente en un momento determinado para modificar su farmacocin\u00e9tica.  en la fase inicial del estudio se han desarrollado las t\u00e9cnicas anal\u00edticas para la determinaci\u00f3n del metotrexato en plasma y bilis de rata, se ha dise\u00f1ado el tiempo \u00f3ptimo de toma de muestra plasm\u00e1tica y se han aplicado las t\u00e9cnicas quir\u00fargicas necesarias para la administraci\u00f3n de metotrexato y la recogida de muestras plasm\u00e1ticas y biliares.  para caracterizar como se modifica el comportamiento cin\u00e9tico del metotrexato en presencia de colestipol se ha desarrollado el modelo bicompartimental cl\u00e1sico para determinar los par\u00e1metros farmacocin\u00e9ticos del metotrexato, el modelo biliar para cuantificar el porcentaje de eliminaci\u00f3n del metotrexato por esta v\u00eda, el modelo no compartimental para evaluar la eficacia de la resina en t\u00e9rminos de reducci\u00f3n del \u00e1rea bajo la curva del metotrexato y el modelo farmacoestad\u00edstico con el que se realiza un an\u00e1lisis integral del comportamiento cin\u00e9tico en los distintos grupos de ensayo. Los resultados obtendios indican que el colestipol reduce los niveles plasm\u00e1ticos en un 28.41% a partir de la primera dosis administrada &#8230; Los par\u00e1metros farmacocin\u00e9ticos de tendencia central para el metotrexato, en la rata, presentan una variabilidad residual del 51,96% +- 15,52 y variabilidad interindividual para el aclaramiento de 19,80% (7,61). La validaci\u00f3n del modelo farmaco estad\u00edstico indica la ausencia de sesgo sistem\u00e1tico respecto a la l\u00ednea identidad en los valores medios de las predicciones realizadas. El pr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelo animal para el estudio de la recirculaci\u00f3n corporal del metotrexato y su interrupci\u00f3n con colestipol.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelo animal para el estudio de la recirculaci\u00f3n corporal del metotrexato y su interrupci\u00f3n con colestipol. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandra G\u00f3mez Palomo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victor Jimenez Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Rius alarc\u00f3n <\/li>\n<li>Juan  pablo Ordovas baines (vocal)<\/li>\n<li>agust\u00edn S\u00e1nchez alcaraz (vocal)<\/li>\n<li>eduardo Mari\u00f1o hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandra G\u00f3mez Palomo Se ha dise\u00f1ado un modelo animal para el estudio de la farmacocin\u00e9tica del metotrexato [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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