{"id":111077,"date":"2018-03-11T10:37:27","date_gmt":"2018-03-11T10:37:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-actividades-rna-ligasa-implicadas-en-la-replicacion-de-los-viroides-nucleares-y-cloroplasticos\/"},"modified":"2018-03-11T10:37:27","modified_gmt":"2018-03-11T10:37:27","slug":"caracterizacion-de-actividades-rna-ligasa-implicadas-en-la-replicacion-de-los-viroides-nucleares-y-cloroplasticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/politecnica-de-valencia\/caracterizacion-de-actividades-rna-ligasa-implicadas-en-la-replicacion-de-los-viroides-nucleares-y-cloroplasticos\/","title":{"rendered":"Caracterizaci\u00f3n de actividades rna ligasa implicadas en la replicaci\u00f3n de los viroides nucleares y cloropl\u00e1sticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda \u00e1ngeles Nohales Zafra <\/strong><\/h2>\n<p>Los viroides son peque\u00f1os rnas circulares de cadena sencilla (246-401 nt) pat\u00f3genos de plantas. A pesar de su peque\u00f1o tama\u00f1o y de no codificar prote\u00ednas, son capaces de replicarse aut\u00f3nomamente, moverse sist\u00e9micamente y, en la mayor\u00eda de los casos, provocar enfermedades en sus plantas hu\u00e9sped. La replicaci\u00f3n de los viroides ocurre a trav\u00e9s de un mecanismo de c\u00edrculo rodante con intermediarios de rna que consta de tres etapas: (1) transcripci\u00f3n rna-rna que origina rnas oligom\u00e9ricos de polaridad complementaria, (2) procesamiento de algunos de estos olig\u00f3meros a mon\u00f3meros lineales, y (3) circularizaci\u00f3n de estos \u00faltimos. Puesto que los viroides no codifican prote\u00ednas, su replicaci\u00f3n depende de la interacci\u00f3n del rna viroidal con factores del hu\u00e9sped. La etapa menos conocida de este ciclo replicativo es la ligaci\u00f3n de los mon\u00f3meros lineales para generar el producto de la replicaci\u00f3n, la forma circular mon\u00f3merica. As\u00ed pues, los objetivos de esta tesis doctoral han sido: 1) identificar los factores del hu\u00e9sped implicados en la ligaci\u00f3n de los viroides nucleares (familia pospiviroidae) y cloropl\u00e1sticos (familia avsunviroidae) durante su replicaci\u00f3n, empleando los sistemas experimentales viroide del tub\u00e9rculo fusiforme de la pata (pstvd)-tomate y viroide latente de la berenjena (elvd)-berenjena. 2) caracterizar la interacci\u00f3n de estos factores con los rnas viroidales desde un punto de vista bioqu\u00edmico y funcional. en el caso de los viroides nucleares, se ha identificado la dna ligasa 1 como el factor probablemente implicado en la ligaci\u00f3n de los rnas monom\u00e9ricos lineales. Respecto a los viroides cloropl\u00e1sticos, diferentes ensayos in vitro han puesto de manifiesto que la trna ligasa es muy probablemente el factor del hu\u00e9sped implicado en la ligaci\u00f3n de los intermediarios replicativos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de actividades rna ligasa implicadas en la replicaci\u00f3n de los viroides nucleares y cloropl\u00e1sticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de actividades rna ligasa implicadas en la replicaci\u00f3n de los viroides nucleares y cloropl\u00e1sticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda \u00e1ngeles Nohales Zafra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Polit\u00e9cnica de Valencia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/09\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Dar\u00f3s Arnau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Pall\u00e1s benet <\/li>\n<li>pedro Carrasco sorl\u00ed (vocal)<\/li>\n<li>Francisco Tenllado peralo (vocal)<\/li>\n<li>Fernando Ponz ascaso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda \u00e1ngeles Nohales Zafra Los viroides son peque\u00f1os rnas circulares de cadena sencilla (246-401 nt) pat\u00f3genos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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