{"id":111096,"date":"2018-03-11T10:37:27","date_gmt":"2018-03-11T10:37:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activation-of-the-bmp4-pathway-and-early-expression-of-cdx2-characterize-non-specialized-columnar-metaplasia-in-a-human-model-of-barrettas-esophagus\/"},"modified":"2018-03-11T10:37:27","modified_gmt":"2018-03-11T10:37:27","slug":"activation-of-the-bmp4-pathway-and-early-expression-of-cdx2-characterize-non-specialized-columnar-metaplasia-in-a-human-model-of-barrettas-esophagus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activation-of-the-bmp4-pathway-and-early-expression-of-cdx2-characterize-non-specialized-columnar-metaplasia-in-a-human-model-of-barrettas-esophagus\/","title":{"rendered":"Activation of the bmp4 pathway and early expression of cdx2 characterize non-specialized columnar metaplasia in a human model of barrett\u00c2\u00bfs esophagus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Castillo Ramos <\/strong><\/h2>\n<p>Antecedentes: modelo humano de reflujo gastroesof\u00e1gico utilizado para examinar la contribuci\u00f3n de un epitelio no especializado columnar (nsce) y los principales eventos moleculares (bmp4 y cdx2) implicados en el desarrollo del es\u00f3fago de barrett. m\u00e9todos: biopsias del remanente esof\u00e1gico de 18 pacientes sometidos a esofagectom\u00eda fueron tomadas de 6 a 36 meses despu\u00e9s de la operaci\u00f3n. Se analiz\u00f3 la activaci\u00f3n de la v\u00eda de bmp4 (psmad1\/5\/8) y la expresi\u00f3n de cdx2 y cdx1 por inmunohistoqu\u00edmica, pcr cuantitativa en tiempo real, western blot e ish. resultados: un segmento corto (media: 15,6 mm) de nsce se detect\u00f3 en 10 (56%) pacientes, con preValencia del 17% a los 6 meses y 62% a los 36 meses. Se observ\u00f3 fuerte expresi\u00f3n nuclear de psmad1\/5\/8 en la mucosa cerca de la anastomosis. Cuarenta y ocho (63%) biopsias con nsce mostraron expresi\u00f3n nuclear de cdx2. Dos casos mostraron gl\u00e1ndulas aisladas con expresi\u00f3n completa en todas las c\u00e9lulas de cdx2 y co-expresi\u00f3n de cdx1. Los niveles de arnm de bmp4 y cdx2 fueron significativamente mayores en nsce que en el epitelio escamoso. conclusiones: la activaci\u00f3n de bmp4 en nsce y la expresi\u00f3n temprana de cdx2 est\u00e1n implicados en la diferenciaci\u00f3n del epitelio columnar del es\u00f3fago de barrett<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activation of the bmp4 pathway and early expression of cdx2 characterize non-specialized columnar metaplasia in a human model of barrett\u00c2\u00bfs esophagus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activation of the bmp4 pathway and early expression of cdx2 characterize non-specialized columnar metaplasia in a human model of barrett\u00c2\u00bfs esophagus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Castillo Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/09\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Pera  Rom\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Cardesa Garc\u00eda <\/li>\n<li>vicente Munitiz ruiz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Castillo Ramos Antecedentes: modelo humano de reflujo gastroesof\u00e1gico utilizado para examinar la contribuci\u00f3n de un epitelio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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