{"id":111103,"date":"2018-03-11T10:37:31","date_gmt":"2018-03-11T10:37:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biopela%c2%adculas-de-candida-produccion-de-enzimas-hidrola%c2%adticas-resistencia-a-los-antifungicos-y-asociacion-con-staphylococcus-en-la-estomatitis-protetica\/"},"modified":"2018-03-11T10:37:31","modified_gmt":"2018-03-11T10:37:31","slug":"biopela%c2%adculas-de-candida-produccion-de-enzimas-hidrola%c2%adticas-resistencia-a-los-antifungicos-y-asociacion-con-staphylococcus-en-la-estomatitis-protetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia-clinica\/biopela%c2%adculas-de-candida-produccion-de-enzimas-hidrola%c2%adticas-resistencia-a-los-antifungicos-y-asociacion-con-staphylococcus-en-la-estomatitis-protetica\/","title":{"rendered":"Biopel\u00edculas de candida, producci\u00f3n de enzimas hidrol\u00edticas, resistencia a los antif\u00fangicos y asociaci\u00f3n con staphylococcus en la estomatitis prot\u00e9tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Marcos Arias <\/strong><\/h2>\n<p>La estomatitis prot\u00e9tica es una enfermedad de etiolog\u00eda multifactorial que se asocia con la presencia de candida en las lesiones. Se cree que en su patogenia tienen un papel importante  la producci\u00f3n de biopel\u00edcula y de enzimas hidrol\u00edticas por candida. Adem\u00e1s, podr\u00edan contribuir en el desarrollo y mantenimiento de la estomatitis prot\u00e9tica, la interacci\u00f3n entre diferentes especies de candida, el desarrollo de resistencias a los f\u00e1rmacos antif\u00fangicos o la asociaci\u00f3n con bacterias, como staphylococcus aureus, staphylococcus epidermidis y otros estafilococos.  en esta tesis doctoral, el aislamiento de candida albicans, la presencia de una elevada celularidad f\u00fangica y el aislamiento conjunto de candida y staphylococcus se han podido relacionar con la presencia de estomatitis prot\u00e9tica. Sin embargo, la producci\u00f3n de enzimas hidrol\u00edticas, como proteasas y fosfolipasas, no parece ser un factor de virulencia determinante en el desarrollo de las lesiones. Tambi\u00e9n, se ha observado que candida albicans es la especie m\u00e1s productora de biopel\u00edcula sobre superficies de poliestireno junto con candida tropicalis, siendo ambas componentes habituales en las biopel\u00edculas mixtas de la cavidad oral de portadores de pr\u00f3tesis. Sin embargo, exist\u00eda una gran variabilidad entre los aislamientos cl\u00ednicos en la capacidad de producir esta biopel\u00edcula. Finalmente, a pesar de que los tratamientos t\u00f3picos (con anfotericina b, nistatina o miconazol) u oral (con fluconazol o itraconazol) de la estomatitis prot\u00e9tica podr\u00edan inducir la selecci\u00f3n de aislamientos o especies resistentes, se ha observado una actividad in vitro excelente de anfotericina b, miconazol y fluconazol. Adem\u00e1s, el estudio de la actividad in vitro de nuevos f\u00e1rmacos az\u00f3licos (posaconazol y voriconazol), de equinocandinas (anidulafungina y micafungina) o de compuestos naturales (carvacrol, eugenol, linalool y terpinen-4-ol ) han demostrado gran eficacia y pueden ser alternativas \u00fatiles para el tratamiento de la estomatitis prot\u00e9tica y la candidiasis oral recurrentes o recalcitrantes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biopel\u00edculas de candida, producci\u00f3n de enzimas hidrol\u00edticas, resistencia a los antif\u00fangicos y asociaci\u00f3n con staphylococcus en la estomatitis prot\u00e9tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biopel\u00edculas de candida, producci\u00f3n de enzimas hidrol\u00edticas, resistencia a los antif\u00fangicos y asociaci\u00f3n con staphylococcus en la estomatitis prot\u00e9tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Marcos Arias <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/09\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Quindos Andres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Aguirre urizar <\/li>\n<li>alfonso j. Carrillo mu\u00f1oz (vocal)<\/li>\n<li>josep Guarro artigas (vocal)<\/li>\n<li>Jos\u00e9 Francisco Cano lira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Marcos Arias La estomatitis prot\u00e9tica es una enfermedad de etiolog\u00eda multifactorial que se asocia con la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1085,7840,984,597,12909],"tags":[219985,221510,13560,148040,137817,7013],"class_list":["post-111103","post","type-post","status-publish","format-standard","hentry","category-enfermedades-infecciosas","category-hongos","category-levaduras","category-microbiologia-clinica","category-pais-vasco-euskal-herriko-unibertsitatea","tag-alfonso-j-carrillo-munoz","tag-cristina-marcos-arias","tag-guillermo-quindos-andres","tag-jose-francisco-cano-lira","tag-jose-manuel-aguirre-urizar","tag-josep-guarro-artigas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/111103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=111103"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/111103\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=111103"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=111103"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=111103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}