{"id":11116,"date":"2001-05-06T00:00:00","date_gmt":"2001-05-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-del-grado-de-metilacion-del-gen-de-la-calcitonina-en-pacientes-con-leucemia-agudas\/"},"modified":"2001-05-06T00:00:00","modified_gmt":"2001-05-06T00:00:00","slug":"analisis-del-grado-de-metilacion-del-gen-de-la-calcitonina-en-pacientes-con-leucemia-agudas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analisis-del-grado-de-metilacion-del-gen-de-la-calcitonina-en-pacientes-con-leucemia-agudas\/","title":{"rendered":"An\u00e1lisis del grado de metilacion del gen de la calcitonina en pacientes con leucemia agudas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Castillejo Enriquez Juan  Antonio <\/strong><\/h2>\n<p>Analizamos la hipermetilaci\u00f3n del gen de la calcitonina calc1 usando la reacci\u00f3n en cadena de la polimerasa semicuantitativa diferencial en 105 pacientes con leucemia aguda linfabl\u00e1stica lal infantil (n=56) y del adulto (n=49) y estudiamos la asociaci\u00f3n de la hipermetilaci\u00f3n calc1 con los aspectos cl\u00ednicos al diagn\u00f3stico y desarrollo de la enfermedad. Tambi\u00e9n investigamos la posible relaci\u00f3n entre el estado de metilaci\u00f3n calc1 y la expresi\u00f3n del gen inhibidor del ciclo celular p57kip2. Observamos hipermetilaci\u00f3n calc1 en c\u00e9lulas de m\u00e9dula \u00f3sea en el 45% (45\/105) de los pacientes. Los aspectos cl\u00ednicos, moleculares y de laboratorio no difer\u00edan significativamente entre pacientes hipermetilados e hipometilados.S\u00f3lo las lal de l\u00ednea t se asociaban con hipermtilaci\u00f3n (145 vs 47%, p=0,025). Los porcentajes de remisi\u00f3n completa fueron similares en ambos grupos, aunque los pacientes hipermetilados presentaban m\u00e1s reca\u00eddas (68% vs 195, p&lt;0,0001) y m\u00e1s mortalidad (55% vs 36%, p=0,06) que los pacientes hipometilados. La supervivencia libre de enfermedad a los 6 a\u00f1os fue del 66,1% para pacientes hipometilados y del 5,3% para hipermetilados (p&gt;0,0001). El an\u00e1lisis multivariable de los potenciales factores pron\u00f3sticos demostr\u00f3 que la metilaci\u00f3n del gen calc1 es un factor pron\u00f3stico independiente. El an\u00e1lisis separado de lal del adulto e infantil mostr\u00f3 los mismos resultados que la serie global. adem\u00e1s, los pacientes hipermetilados mostraban falta de expresi\u00f3n del gen p57kip2. Nuestros resultados sugieren que la hipermetilaci\u00f3n del gen calc1 est\u00e1 asociada con un aumento del riesgo de reca\u00edda independientemente de factores de riesgo conocidos y describe por primera vez una posible implicaci\u00f3n del gen p57kip2 en la g\u00e9nesis y pron\u00f3stico de las lal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis del grado de metilacion del gen de la calcitonina en pacientes con leucemia agudas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis del grado de metilacion del gen de la calcitonina en pacientes con leucemia agudas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Castillejo Enriquez Juan  Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Rom\u00e1n G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Jim\u00e9nez perep\u00e9rez <\/li>\n<li>Miguel \u00e1ngel Sanz alonso (vocal)<\/li>\n<li>carmen Martin calvo (vocal)<\/li>\n<li>pascual Bolufer gilabert (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Castillejo Enriquez Juan Antonio Analizamos la hipermetilaci\u00f3n del gen de la calcitonina calc1 usando la reacci\u00f3n en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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