{"id":11119,"date":"2001-05-06T00:00:00","date_gmt":"2001-05-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-atp-asa-de-protones-de-membrana-plasmatica-de-cryptococcus-neoformans-caracterizacion-genetica-y-bioquimica\/"},"modified":"2001-05-06T00:00:00","modified_gmt":"2001-05-06T00:00:00","slug":"la-atp-asa-de-protones-de-membrana-plasmatica-de-cryptococcus-neoformans-caracterizacion-genetica-y-bioquimica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-atp-asa-de-protones-de-membrana-plasmatica-de-cryptococcus-neoformans-caracterizacion-genetica-y-bioquimica\/","title":{"rendered":"La atp asa de protones de membrana plasmatica de cryptococcus neoformans: caracterizacion genetica y bioquimica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gorgojo Martinez M. Bego\u00f1a <\/strong><\/h2>\n<p>Se ha clonado el cdna del gen de la atpasa de protones de membrana plasm\u00e1tica de cryptococcus neoformans var.Neoformans. Este tiene una longitud de 3475 pb y presenta un marco de lectura abierto de 2994 pb. La secuencia de aminoacidos deducida presenta un tama\u00f1o de 997 aminoacidos, con una masa molecular de 108.682 da., Constituyendo la proteina pma descrita de mayor longitud. el perfil hidropatico de pma1 presenta 10 supuestos segmentos transmembrana que concuerda con el modelo de estructura secundaria sugerido para todas las atpasas de tipo p. En su secuencia de amino\u00e1cidos se identifican las regiones conservadas presentas en todas las atpasas de tipo p. Igualmente, se han identificado la mayoria de los residuos conservados entre las atpasas transportadoras de protones.  la secuencia de aminoacidos de cnpma1 comparte una mayor homolog\u00eda de secuencia con la atpasa de protones de membrana plasmatica del hongo basidiomiceto uromyces fabae y con las atpasas de protones de plantas, mostrando una menor homolog\u00eda con las de hongos pertenecientes o relacionados con la division ascomycotina.  se ha conseguido complementar una cepa de saccharomyces cerevisiae defectiva en sus genes pma1 y pma2, demostrando asi que el cdna clonado es una atpasa de protones de membrana plasmatica.  a partir de la proteina expresada de forma heterologa se ha estudiado a nivel bioquimico sus constantes cineticas y se han comparado con las de la proteina pma de s.Cerevisiae. A diferencia de esta ultima, la pma de c.Neoformans parece no activarse por glucosa.  se ha reconstituido la membrana plasmatica con la atpasa pma1 de c.Neoformans en proteoliposomas. En este sistema se ha estudiado el bombeo de protones por parte de la enzima, probandose que es una atpasa transportadora de protones susceptible de ser inhibida por el protonoforo fccp.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La atp asa de protones de membrana plasmatica de cryptococcus neoformans: caracterizacion genetica y bioquimica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La atp asa de protones de membrana plasmatica de cryptococcus neoformans: caracterizacion genetica y bioquimica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gorgojo Martinez M. Bego\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Martinez Suarez Joaquin V.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Mart\u00ednez peinado <\/li>\n<li>francisca Vicente perez (vocal)<\/li>\n<li>Fernando Baquero mochales (vocal)<\/li>\n<li>teresa Suarez gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gorgojo Martinez M. Bego\u00f1a Se ha clonado el cdna del gen de la atpasa de protones de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[2719,15401,36551,2604,36552,36553],"class_list":["post-11119","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-fernando-baquero-mochales","tag-francisca-vicente-perez","tag-gorgojo-Martinez-m-begona","tag-jose-Martinez-peinado","tag-Martinez-suarez-joaquin-v","tag-teresa-suarez-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=11119"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11119\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=11119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=11119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=11119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}