{"id":111199,"date":"2018-03-11T10:37:36","date_gmt":"2018-03-11T10:37:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/p120-catenin-and-rac1-key-players-in-canonical-wnt-signaling\/"},"modified":"2018-03-11T10:37:36","modified_gmt":"2018-03-11T10:37:36","slug":"p120-catenin-and-rac1-key-players-in-canonical-wnt-signaling","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/p120-catenin-and-rac1-key-players-in-canonical-wnt-signaling\/","title":{"rendered":"P120-catenin and rac1: key players in canonical wnt signaling"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gabriela Valls Sierra <\/strong><\/h2>\n<p>A recent role for rac1 gtpase in canonical wnt signaling was recently demonstrated, being required for \u00edY-catenin translocation to the nucleus. We find that rac1 is stimulated in sw-480 or hek-293 cells upon wnt3a addition. This up-regulation temporally correlates with p120-catenin direct binding to rac1 and vav2, an association that happens after the release of p120-catenin from e-cadherin. P120-catenin and vav2 are required for rac1 stimulation by wnt3a, and for \u00edY-catenin translocation to the nucleus. The interaction of rac1 and vav2 with p120-catenin increases upon serine\/threonine phosphorylation by ck1 and tyrosine dephosphorylation of p120-catenin, two modifications stimulated by wnt3a. When over-expressed, p120-catenin mutants unable to bind rac1 or vav2 fail to stimulate rac1 activity. Moreover, since p120-catenin depletion disrupts gastrulation in xenopus, we analyzed p120-catenin mutants for their ability to rescue this phenotype. In contrast to the wild-type protein or other controls, p120-catenin point mutants unable to bind rac1 or vav2, failed to rescue p120 depletion. Collectively, these results indicate that p120-catenin is required for rac1 activation upon wnt signaling, through binding to vav2 and rac1 proteins.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>P120-catenin and rac1: key players in canonical wnt signaling<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 P120-catenin and rac1: key players in canonical wnt signaling <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gabriela Valls Sierra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/09\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mireia Du\u00f1ach MasJuan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Vinyals canals <\/li>\n<li>salvador Aznar benitah (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gabriela Valls Sierra A recent role for rac1 gtpase in canonical wnt signaling was recently demonstrated, being [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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