{"id":111348,"date":"2011-11-10T00:00:00","date_gmt":"2011-11-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcionalidad-de-la-prpc-en-celulas-troncales-embrionarias-de-raton-y-susceptibilidad-diferencial-a-scrapie-de-sus-polimorfismos-en-cabra\/"},"modified":"2011-11-10T00:00:00","modified_gmt":"2011-11-10T00:00:00","slug":"funcionalidad-de-la-prpc-en-celulas-troncales-embrionarias-de-raton-y-susceptibilidad-diferencial-a-scrapie-de-sus-polimorfismos-en-cabra","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/funcionalidad-de-la-prpc-en-celulas-troncales-embrionarias-de-raton-y-susceptibilidad-diferencial-a-scrapie-de-sus-polimorfismos-en-cabra\/","title":{"rendered":"Funcionalidad de la prpc en c\u00e9lulas troncales embrionarias de rat\u00f3n y susceptibilidad diferencial a scrapie de sus polimorfismos en cabra."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Miranda Bedate <\/strong><\/h2>\n<p>La tesis doctoral con t\u00edtulo \u00c2\u00bffuncionalidad de la prpc en c\u00e9lulas troncales embrionarias de rat\u00f3n y susceptibilidad diferencial a scrapie de sus polimorfismos en cabra\u00c2\u00bf versa sobre la capacidad de esta prote\u00edna, implicada en la patog\u00e9nesis de las enf ermedades pri\u00f3nicas, en el mantenimiento de la pluripotencia y en la diferenciaci\u00f3n temprana de las c\u00e9lulas troncales. As\u00ed, se ha descubierto que su expresi\u00f3n regula la transcripci\u00f3n de un marcador importante de pluripotencia, nanog, y que esta depen dencia transcripcional est\u00e1 mediada por una compleja matriz de integrinas. As\u00ed mismo, nos encontramos ante la primera funci\u00f3n no redundante descrita para la prpc, ni siquiera compensada por las prote\u00ednas de su misma familia doppel y shadoo, ya que su  ausencia genera dos poblaciones de cuerpos embrioides en cultivo, una de las cuales expresa marcadores de pgcs (c\u00e9lulas primordiales germinales) durante toda la diferenciaci\u00f3n temprana. Por otro lado, el polimorfismo de la prpc q222k, sospechoso de conferir resistencia in vivo al desarrollo del scrapie en un peque\u00f1o rumiante como es la cabra, confirma este hecho en las l\u00edneas de rat\u00f3n transg\u00e9nico generadas a tal efecto. La l\u00ednea que porta este polimorfismo exhibe unos tiempos de incubaci\u00f3n de l a enfermedad significativamente superiores a la l\u00ednea con genotipo wt cuando a ambas se les inocula con un aislado espa\u00f1ol de scrapie. De esta forma, se sugiere un descenso de susceptibilidad frente a la enfermedad, hecho que podr\u00eda ser \u00fatil en los p rogramas de selecci\u00f3n gen\u00e9tica en la caba\u00f1a ganadera caprina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funcionalidad de la prpc en c\u00e9lulas troncales embrionarias de rat\u00f3n y susceptibilidad diferencial a scrapie de sus polimorfismos en cabra.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funcionalidad de la prpc en c\u00e9lulas troncales embrionarias de rat\u00f3n y susceptibilidad diferencial a scrapie de sus polimorfismos en cabra. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Miranda Bedate <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/10\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Gutierrez Ad\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Molina mart\u00edn <\/li>\n<li>johan albert Schoorlemmer (vocal)<\/li>\n<li>bel\u00e9n Pintado sanJuan benito (vocal)<\/li>\n<li>Jes\u00fas Rodr\u00edguez requena (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Miranda Bedate La tesis doctoral con t\u00edtulo \u00c2\u00bffuncionalidad de la prpc en c\u00e9lulas troncales embrionarias de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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