{"id":111477,"date":"2018-03-11T10:38:01","date_gmt":"2018-03-11T10:38:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sa%c2%adntesis-y-evaluacion-biologica-de-nuevos-derivados-de-pirido23-dpirimidina-y-quinazolina-con-actividad-antitumoral-valoracion-de-su-capacidad-antimetastasica\/"},"modified":"2018-03-11T10:38:01","modified_gmt":"2018-03-11T10:38:01","slug":"diseno-sa%c2%adntesis-y-evaluacion-biologica-de-nuevos-derivados-de-pirido23-dpirimidina-y-quinazolina-con-actividad-antitumoral-valoracion-de-su-capacidad-antimetastasica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/diseno-sa%c2%adntesis-y-evaluacion-biologica-de-nuevos-derivados-de-pirido23-dpirimidina-y-quinazolina-con-actividad-antitumoral-valoracion-de-su-capacidad-antimetastasica\/","title":{"rendered":"Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica de nuevos derivados de pirido[2,3-d]pirimidina y quinazolina con actividad antitumoral. valoraci\u00f3n de su capacidad antimetast\u00e1sica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Moreno Amatria <\/strong><\/h2>\n<p>?Design, synthesis and biological evaluation of novel pyirido[2,3-d]pyrimidine and quinazoline derivatives with antitumoral activity. Valoration of their antimetastatic capacity\u00c2\u00bf esther moreno amatria. School of pharmacy. University of navarra (spain), 2011  the disease of cancer has been ranked as a major health burden. Pyrido[2,3-d]pyrimidine and quinazoline derivatives have attracted attention due to their broad range of pharmacological activities: antifungal, antimalarial, anti-inflammatory, anticonvulsant, antibacterial, antihypertensive, and their anticancer activity is one of the most promising aspects as they act through multiple targets. Based on these observations and considering our experience with these heteroaromatic rings, we have synthesized 57 novel 2,4-disubstituted quinazoline and pyrido[2,3-d]pyrimidine derivatives.  these compounds have been screened in vitro against five tumoral cell lines \u00c2\u00bf prostate (pc-3), leukemia (ccrf-cem), colon (ht-29), lung (htb-54) and breast (mcf-7) \u00c2\u00bf and two cell lines derived from non-malignant cell lines, one mammary (184b5) and one from bronchial epithelium (beas-2b). Mcf-7 and htb-54 have been the most sensitive cell lines with gi50 values below 10 \u00ed\u00acm for eleven and ten compounds, respectively. Two compounds (i.3 and iv.14) evoke a marked cytotoxic effect in all cell lines tested and one compound, iv.7, has been potent and selective against mcf-7. A preliminary study into the mechanism of the potent derivatives i.3, iv.7 and iv.14 indicates that the cytotoxic activities of these compounds might be mediated by inducing cell death without modifications on cell cycle. Moreover, the signaling pathway implicated in the cell death observed upon treatment in mcf-7 cells by compound iv.14 could be akt\/s6 ribosomal\/m-tor. the lead compounds induce inhibition of cell migration in mda-mb-231 cells and in this inhibition of migration the kinases akt, s6 ribosomal, fak and src are not implicated.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica de nuevos derivados de pirido[2,3-d]pirimidina y quinazolina con actividad antitumoral. valoraci\u00f3n de su capacidad antimetast\u00e1sica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica de nuevos derivados de pirido[2,3-d]pirimidina y quinazolina con actividad antitumoral. valoraci\u00f3n de su capacidad antimetast\u00e1sica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Moreno Amatria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/10\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Carmen Sanmart\u00edn Grijalba<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda del pilar Cabildo miranda <\/li>\n<li>Ana Mar\u00eda Ochoa de retana mendibil (vocal)<\/li>\n<li>dahlia Doughty shenton (vocal)<\/li>\n<li>ignacio Jos\u00e9 Encio Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Moreno Amatria ?Design, synthesis and biological evaluation of novel pyirido[2,3-d]pyrimidine and quinazoline derivatives with antitumoral activity. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749,416],"tags":[222107,222108,222105,18279,32244,222106],"class_list":["post-111477","post","type-post","status-publish","format-standard","hentry","category-navarra","category-quimica-organica","tag-ana-maria-ochoa-de-retana-mendibil","tag-dahlia-doughty-shenton","tag-esther-moreno-amatria","tag-ignacio-jose-encio-Martinez","tag-maria-del-carmen-sanmartin-grijalba","tag-maria-del-pilar-cabildo-miranda"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/111477","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=111477"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/111477\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=111477"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=111477"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=111477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}