{"id":111525,"date":"2018-03-11T10:38:06","date_gmt":"2018-03-11T10:38:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/advanced-classical-hodgkin-lymphoma-new-insights-in-prognostic-factors-using-gene-and-microrna-expression-signatures\/"},"modified":"2018-03-11T10:38:06","modified_gmt":"2018-03-11T10:38:06","slug":"advanced-classical-hodgkin-lymphoma-new-insights-in-prognostic-factors-using-gene-and-microrna-expression-signatures","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/advanced-classical-hodgkin-lymphoma-new-insights-in-prognostic-factors-using-gene-and-microrna-expression-signatures\/","title":{"rendered":"Advanced classical hodgkin lymphoma: new insights in prognostic factors using gene and microrna expression signatures."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz S\u00e1nchez Espiridi\u00f3n <\/strong><\/h2>\n<p>Classical hodgkin lymphoma (chl) is assumed to be a curable tumor, but an important  fraction of patients with advanced disease do not respond favorably to the standard  chemotherapy regimens based on adriamycin and current predictive systems, based on clinical  and analytical parameters, fail to accurately identify these high risk patients. Thus, the  identification of biomarkers associated with treatment response remains a critical challenge in  this lymphoid malignancy.   chl represents a distinctive model of histological complexity, with a minor population  of the characteristic tumor cells, the hodgkin and  reed sternberg cells (hrs) diluted in a  complex reactive inflammatory background. The intrinsic relationship between the hrs cells  and their microenvironment is only partially understood but important advances in the  understanding of the chl pathophysiology are being  made. Indeed, microarray expression  studies of tumor samples have led to the identification of signatures and biological processes  associated to hodgkin\u00c2\u00bfs lymphoma pathogenesis and treatment response, showing that  outcome in chl patients could be related with both  biological characteristic components of  chl tumors. However, no steps towards the translation of gene profiling results into routine  clinical practice have been made.  this study identified gene subsets expressed either by the tumoral hrs cells and the  hodgkin\u00c2\u00bfs microenvironment showing that robust methodologies based on quantitative realtime-pcr- (rt-pcr) assays are suitable for expression profiling of tumors and can be easily  applied to paraffin-embedded samples. By a sequential analysis process, functional gene  signatures associated with treatment response were first identified and finally a quantitative  rt-pcr assay for patients with advanced chl was described, incorporating a limited number of  genes and pathways from tumor and microenvironment  cell components, designed for  application to routine formalin-fixed paraffin-embedded samples. This model was able to  identify patient subgroups with highly different probabilities of treatment failure. Additionally,  it was able to incorporate one of the well established clinical variables (stage iv), thus  integrating the main biological and molecular characteristics of the tumors related with  treatment response and the tumor burden estimation in a single scoring system.   micrornas (mirnas) have been described to be essential regulators of cell  differentiation and biological processes, emerging as robust predictor and prognostic markers.  specific signatures from the hrs cells and their microenvironment have been proposed, but  the potential prognostic role of them remains unclear. Thus, this study additionally  investigated whether mirna signatures could allow to a better understanding of chl  pathogenesis and identified a chl mirna signature related to treatment response.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Advanced classical hodgkin lymphoma: new insights in prognostic factors using gene and microrna expression signatures.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Advanced classical hodgkin lymphoma: new insights in prognostic factors using gene and microrna expression signatures. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz S\u00e1nchez Espiridi\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Piris Pinilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fernandez piqueras <\/li>\n<li>jeronimo Forteza vila (vocal)<\/li>\n<li>Mar\u00eda no Provencio pulla (vocal)<\/li>\n<li>Jos\u00e9 \u00e1ngel Mart\u00ednez climent (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz S\u00e1nchez Espiridi\u00f3n Classical hodgkin lymphoma (chl) is assumed to be a curable tumor, but an important [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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