{"id":111656,"date":"2011-02-11T00:00:00","date_gmt":"2011-02-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/epigenetic-regulation-of-clonally-variant-gene-expression-in-plasmodium-falciparum\/"},"modified":"2011-02-11T00:00:00","modified_gmt":"2011-02-11T00:00:00","slug":"epigenetic-regulation-of-clonally-variant-gene-expression-in-plasmodium-falciparum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia\/epigenetic-regulation-of-clonally-variant-gene-expression-in-plasmodium-falciparum\/","title":{"rendered":"Epigenetic regulation of clonally variant gene expression in plasmodium falciparum"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Valerie Margarita Crowley <\/strong><\/h2>\n<p>La variaci\u00f3n clonal en la expresi\u00f3n g\u00e9nica (cvge seg\u00fan sus sigla en ingl\u00e9s), es una estrategia de supervivencia com\u00fan utilizada por muchos pat\u00f3genos, incluyendo el par\u00e1sito de la malaria plasmodium falciparum. Entre los genes que muestran cvge hay diversos miembros de la familia clag i eba. El estado activo o inactivo de clag3.1, clag3.2 i eba-140 se transmite epigen\u00e9ticamente y se controla por el estado eucromat\u00ednico de dominios de cromatina biestables, caracterizados respectivamente por h3k9ac i h3k9me. Ambas modificaciones se mantienen durante todo el ciclo asexual para transmitir la informaci\u00f3n epigen\u00e9tica. Hemos caracterizado la cvge a nivel de todo el genoma, y hemos visto que afecta a un gran n\u00famero de genes. Experimentos preliminares con clag3.2 nos demuestran que la cvge de otras familias de genes diferentes a var tambi\u00e9n se puede reproducir en un sistema episomal y proporcionan evidencia preliminar de que la cvge est\u00e1 regulada por la formaci\u00f3n espont\u00e1nea de heterocromatina facultativa. Tambi\u00e9n se ha  estudiado la expresi\u00f3n mutuamente exclusiva de clag3.1 i clag3.2, incluyendo la caracterizaci\u00f3n de un arn no codificante vecino.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Epigenetic regulation of clonally variant gene expression in plasmodium falciparum<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Epigenetic regulation of clonally variant gene expression in plasmodium falciparum <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Valerie Margarita Crowley <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/11\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Llu\u00eds Ribas De Pouplana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Francisco Aramburu beltran <\/li>\n<li>artur Scherf (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Valerie Margarita Crowley La variaci\u00f3n clonal en la expresi\u00f3n g\u00e9nica (cvge seg\u00fan sus sigla en ingl\u00e9s), es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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